Orchard Ané, Viljoen Alvaro, van Vuuren Sandy
Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Department of Pharmaceutical Sciences, Faculty of Sciences, Tshwane, University of Technology, Private Bag X680, Pretoria, 0001, South Africa.
Chem Biodivers. 2018 Dec;15(12):e1800405. doi: 10.1002/cbdv.201800405. Epub 2018 Dec 17.
This study aimed to determine the antimicrobial activity of 247 essential oil combinations against the reference strains of wound pathogens. Essential oil combinations were investigated for antimicrobial activity against five pathogens. The minimum inhibitory concentration (MIC) assay was used and the fractional inhibitory concentration index (ΣFIC) calculated to determine interactions between selected oils. Twenty-six combinations displayed broad-spectrum antimicrobial activity against all five reference strains and several displayed synergy against more than one pathogen. The combination of Santalum austrocaledonicum (sandalwood) with Commiphora myrrha (myrrh) displayed noteworthy antimicrobial activity against all five reference strains and synergy against four (MIC values 0.03-1.00 mg/ml and ΣFIC values 0.19-1.00 mg/ml) pathogens. No antagonism was observed. Santalum spp. and Vetiveria zizanioides essential oils contributed the most to antimicrobial activity in combination. Essential oil combinations are presented as a viable option in wound therapy.
本研究旨在确定247种精油组合对伤口病原体参考菌株的抗菌活性。对精油组合针对五种病原体的抗菌活性进行了研究。采用最低抑菌浓度（MIC）测定法，并计算分数抑菌浓度指数（ΣFIC）以确定所选精油之间的相互作用。26种组合对所有五种参考菌株均表现出广谱抗菌活性，有几种组合对不止一种病原体表现出协同作用。澳洲檀香（檀香木）与没药树（没药）的组合对所有五种参考菌株均表现出显著的抗菌活性，对四种病原体表现出协同作用（MIC值为0.03 - 1.00 mg/ml，ΣFIC值为0.19 - 1.00 mg/ml），未观察到拮抗作用。檀香属植物和香根草精油在组合中对抗菌活性贡献最大。精油组合是伤口治疗中的一个可行选择。
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