木槿提取物、植物蛋白酶和没药对预防复发性单纯性尿路感染患者的症状性尿路感染发作有益。

Hibiscus extract, vegetable proteases and Commiphora myrrha are useful to prevent symptomatic UTI episode in patients affected by recurrent uncomplicated urinary tract infections.

作者信息

Cai Tommaso, Tiscione Daniele, Cocci Andrea, Puglisi Marco, Cito Gianmartin, Malossini Gianni, Palmieri Alessandro

机构信息

Department of Urology, Santa Chiara Regional Hospital, Trento.

出版信息

Arch Ital Urol Androl. 2018 Sep 30;90(3):203-207. doi: 10.4081/aiua.2018.3.203.

DOI:10.4081/aiua.2018.3.203

PMID:30362679

Abstract

OBJECTIVE

To evaluate the efficacy of a combination of Hibiscus extract, vegetable proteases and Commiphora myrrha extract in the prophylaxis of symptomatic episode in women affected by recurrent urinary tract infections (rUTIs).

MATERIALS AND METHODS

In this phase II clinical trial, all patients with history and diagnosis of rUTI were enrolled. All patients underwent the following treatment schedule: 1 tablet in the morning and 1 tablet in the evening for 7 days and, then, 1 tablet in the evening for 10 days (1 cycle every each month, for 6 months) of a combination of Hibiscus extract, vegetable proteases and Commiphora myrrha extract. At the baseline, all patients underwent urologic visit with quality of life (QoL) questionnaires and mid-stream urine culture. After 3 and 6 months, all patients underwent urologic visit, urine culture and QoL questionnaires evaluation.

RESULTS

Fifty-five women were enrolled (mean age 49.3; range: 28-61). At the enrollment time, the most common pathogen was Escherichia coli (63.7%). The median number of UTI per 6 months was 5 (IQR: 4-9). At the end of the second follow-up evaluation, 25 women did not reported any symptomatic episode of UTI (49%), 18 reported less than 2 episodes (35.3%), while 8 reported more than 2 episodes (15.7%). However, at the first and second follow-up evaluation the clinical statistically significant improvement (QoL) was reported by 38/51 (74.5%) (p < 0.001 from baseline) and 43/51 (84.3%) (p < 0.001 from baseline) women, respectively. The median number of UTI decreased to 2 (IQR: 0-3). At the end of the follow-up period, 30/51 had sterile urine (58.8%), while 21/51 (41.2%) reported a transition from symptomatic UTI to asymptomatic bacteriuria.

CONCLUSIONS

In conclusion, this treatment, in motivated patients, is able to prevent symptomatic UTI symptomatic episode and improve patient's QoL.

摘要

目的

评估木槿提取物、植物蛋白酶和没药提取物联合使用对复发性尿路感染（rUTIs）女性预防症状性发作的疗效。

材料与方法

在这项II期临床试验中，纳入了所有有rUTI病史和诊断的患者。所有患者接受以下治疗方案：服用木槿提取物、植物蛋白酶和没药提取物的组合，每天早晚各1片，共7天，然后每晚1片，共10天（每月1个周期，共6个月）。在基线时，所有患者均接受泌尿外科检查，并填写生活质量（QoL）问卷和进行中段尿培养。在3个月和6个月后，所有患者再次接受泌尿外科检查、尿培养和QoL问卷评估。

结果

共纳入55名女性（平均年龄49.3岁；范围：28 - 61岁）。入组时，最常见的病原体是大肠杆菌（63.7%）。每6个月UTI的中位数为5次（四分位间距：4 - 9次）。在第二次随访评估结束时，25名女性未报告任何UTI症状性发作（49%），18名女性报告发作少于2次（35.3%），而8名女性报告发作多于2次（15.7%）。然而，在第一次和第二次随访评估中，分别有38/51（74.5%）（与基线相比p < 0.001）和43/51（84.3%）（与基线相比p < 0.001）的女性报告临床统计学上有显著改善（QoL）。UTI的中位数降至2次（四分位间距：0 - 3次）。在随访期结束时，30/51的患者尿液无菌（58.8%），而21/51（41.2%）的患者从有症状的UTI转变为无症状菌尿。