Department of Oral and Maxillofacial Surgery, State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, Sichuan 610041, P.R. China.
Department of Stomatology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.
Mol Med Rep. 2018 Dec;18(6):5307-5316. doi: 10.3892/mmr.2018.9577. Epub 2018 Oct 23.
Fatty acid (FA) metabolism, including the uptake, de novo synthesis and oxidation of FAs, is critical for the survival, proliferation, differentiation and metastasis of cancer cells. Several bodies of evidence have confirmed the metabolic reprogramming of FAs that occurs during cancer development. The present review aimed to evaluate FAs in terms of how the hallmarks of cancer are gradually established in tumourigenesis and tumour progression, and consider the auxo‑action and exact mechanisms of FA metabolism in these processes. In addition, this interaction in the tumour microenvironment was also discussed. Based on the role of FA metabolism in tumour development, targeting FA metabolism may effectively target cancer, affecting a number of important characteristics of cancer progression and survival.
脂肪酸（FA）代谢，包括 FA 的摄取、从头合成和氧化，对癌细胞的存活、增殖、分化和转移至关重要。有几项证据证实了 FA 在癌症发展过程中的代谢重编程。本综述旨在评估 FA 在肿瘤发生和肿瘤进展过程中如何逐渐建立癌症的标志性特征，并考虑 FA 代谢在这些过程中的辅助作用和确切机制。此外，还讨论了肿瘤微环境中的这种相互作用。基于 FA 代谢在肿瘤发展中的作用，靶向 FA 代谢可能有效地针对癌症，影响癌症进展和存活的许多重要特征。
