Conkar Seçil, Mir Sevgi, Dogan Eser, Ülger Tutar Zulal
Ege University Faculty of Medicine, Department of Pediatric Nephrology, ?zmir, Turkey.
Iran J Kidney Dis. 2018 Oct;12(5):275-280.
It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. The purpose of this study was to research the relationship between 25-hydroxyvitamin D levels and arterial stiffness.
Arterial stiffness was evaluated by measuring augmentation index (AI) and pulse wave velocity (PWV) from the radial and carotid arteries with a Vicorder. The 25-hydroxyvitamin D levels were measured by an immunoassay method.
In the 81 CKD patients (mean age, 13.21 ± 6.02 years; mean body mass index, 19.42 ± 5.12 kg/m2; and 56.8% male), the mean vitamin D level was 60.71 ± 39.52 ng/mL, the mean AI was 7.93 ± 7.77%, and the mean PWV was 9.79 ± 4.36 m/s. Serum levels of 25-hydroxyvitamin D was correlated with AI (r = -0.482, P = 0.001) and PWV (r = -0.57, P = .001).
In this study, it was proven that vitamin D deficiency in children was related to nondiabetic and nondialysis CKD.
众所周知，在慢性肾脏病（CKD）患儿中，心血管损害始于动脉僵硬度增加。除了动脉僵硬度、高血压、肥胖、高胆固醇血症和胰岛素抵抗等传统危险因素外，还有其他危险因素。维生素D缺乏在CKD中相当常见，它被认为是动脉粥样硬化的一个危险因素；然而，其与动脉僵硬度的关系尚不完全清楚。本研究的目的是探讨25-羟基维生素D水平与动脉僵硬度之间的关系。
使用Vicorder通过测量桡动脉和颈动脉的增强指数（AI）和脉搏波速度（PWV）来评估动脉僵硬度。采用免疫测定法测量25-羟基维生素D水平。
在81例CKD患者中（平均年龄13.21±6.02岁；平均体重指数19.42±5.12kg/m²；男性占56.8%），维生素D平均水平为60.71±39.52ng/mL，平均AI为7.93±7.77%，平均PWV为9.79±4.36m/s。血清25-羟基维生素D水平与AI（r = -0.482，P = 0.001）和PWV（r = -0.57，P = 0.001）相关。
本研究证实儿童维生素D缺乏与非糖尿病、非透析的CKD有关。
