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单区域免疫性血小板减少症儿童使用艾曲泊帕的情况

Eltrombopag For Immune Thrombocytopenic Children in a Single Region.

作者信息

Leblebisatan Göksel, Kilinc Yurdanur, Cil Metin, Sasmaz İlgen, Ozkan Ayse

机构信息

1Department of Pediatric Hematology, Çukurova University Medical Faculty, Adana, Turkey.

Adana Numune Research and Education Hospital, Pediatric Hematology-Oncology, Adana, Turkey.

出版信息

Indian J Hematol Blood Transfus. 2018 Oct;34(4):707-710. doi: 10.1007/s12288-018-0928-y. Epub 2018 Feb 5.

Abstract

Child patients of chronic thrombocytopenic purpura with severe and resistant thrombocytopenia were evaluated to observe whether their clinical or laboratory states improve by one of the thrombomimetic therapeutic agent called Eltrombopag as in adults in a single center of different country from previous studies. Nineteen patients with chronic immune thrombocytopenia were treated with Eltrombopag to dose in international guidelines. Approximately half (11/19:58%) of the patients benefitted from the treatment with Eltrombopag either by an increase of platelet levels at safe levels with a decrease in the frequency of bleedings which needed rescue treatment. Thrombomimetic treatment options have strengthened the clinician's hand where the regular treatment options became insufficient.

摘要

对患有严重难治性血小板减少症的慢性血小板减少性紫癜儿童患者进行评估,以观察在不同国家的一个单一中心,一种名为艾曲泊帕的拟血栓形成治疗药物是否能像在成人中一样改善他们的临床或实验室状态,这与之前的研究情况相同。19名慢性免疫性血小板减少症患者按照国际指南服用艾曲泊帕进行治疗。大约一半(11/19:58%)的患者从艾曲泊帕治疗中获益,表现为血小板水平升至安全范围,需要急救治疗的出血频率降低。当常规治疗方法不足时,拟血栓形成治疗方案增强了临床医生的应对能力。

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