State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 199 Renai Road, Suzhou 215123, China.
Nanoscale. 2018 Nov 8;10(43):20126-20130. doi: 10.1039/c8nr05061a.
Computed tomography (CT) is one of the most frequently used diagnostic imaging modalities in clinics. However, the fast clearance of CT contrast agents through the kidney and short circulation time severely restrict their in vivo applications. Herein, taking advantage of the biocompatible CBT condensation reaction, we rationally designed and synthesized a new smart acidic pH/glutathione (GSH) dual-stimuli responsive nanoprobe (1) which can intermolecularly undergo condensation and form a nanoparticle assembly (I-NPs) in the tumour microenvironment. In vivo CT imaging results indicated that probe 1 could be successfully applied for enhanced CT imaging of tumours in nude mice with a low dose of 21.79 mg I per kg body weight, which may offer a promising tool for precise tumor diagnosis.
计算机断层扫描（CT）是临床中最常用的诊断成像方式之一。然而，CT 造影剂在体内通过肾脏快速清除和较短的循环时间严重限制了它们的应用。在此，我们利用生物相容性的 CBT 缩合反应，合理设计并合成了一种新的智能酸性 pH/谷胱甘肽（GSH）双刺激响应纳米探针（1），它可以在肿瘤微环境中通过分子间缩合形成纳米颗粒组装体（I-NPs）。体内 CT 成像结果表明，探针 1 可以在低剂量 21.79 毫克 I/每千克体重的情况下成功应用于裸鼠肿瘤的增强 CT 成像，这可能为精确肿瘤诊断提供一种有前途的工具。
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