Zhang Qi, Cao Xueying, Zhou Jianhui, Ding Rui, Huang Jing, Cai Guangyan, Chen Xiangmei
Department of Nephrology, National Clinical Research Center for Kidney Diseases, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, Beijing, China.
Saudi J Kidney Dis Transpl. 2018 Sep-Oct;29(5):1082-1091. doi: 10.4103/1319-2442.243950.
It has been verified that the red blood cell distribution width (RDW) is related to renal function. This study aimed to investigate the association of RDW with the residual renal function in peritoneal dialysis (PD) patients. The patients were categorized into three groups according to the quartiles of their baseline RDWs. The correlations between RDW and clinical parameters, dialysis adequacy, and residual renal function were analyzed. The clinical data, PD prescription and dialysis adequacy of 54 uremic patients on continuous ambulatory PD were collected. All the statistical analyses were performed using the Statistical Package for the Social Sciences program version 17.0. The baseline RDW of the patients was 13.56% ± 1.36%. No significant differences in the other indexes [hemoglobin, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH), urea and creatinine] among the three groups were found. One month after beginning PD, the correlation between the RDW and the residual renal function has not been found in the multivariate regression model adjusted for the hemoglobin, albumin, and leukocyte. Three months after beginning the PD, a significant difference between Group 2 and Group 3 in iPTH was found. Multivariate regression analysis showed that the elevated RDW is associated with the declined residual glomerular filtration rate (heart rate = -0.587, 95% confidence interval -1.080 ~ -0.093) for the corresponding period after PD, adjusted for the hemoglobin, albumin, and leukocyte. This study showed that the RDW reflected the residual renal function in the corresponding period after PD in the PD patients.
已证实红细胞分布宽度（RDW）与肾功能有关。本研究旨在探讨RDW与腹膜透析（PD）患者残余肾功能之间的关联。根据患者基线RDW的四分位数将其分为三组。分析了RDW与临床参数、透析充分性和残余肾功能之间的相关性。收集了54例接受持续性非卧床腹膜透析的尿毒症患者的临床资料、PD处方和透析充分性。所有统计分析均使用社会科学统计软件包17.0版进行。患者的基线RDW为13.56%±1.36%。三组之间的其他指标[血红蛋白、白蛋白、碱性磷酸酶、全段甲状旁腺激素（iPTH）、尿素和肌酐]未发现显著差异。开始PD一个月后，在调整了血红蛋白、白蛋白和白细胞的多变量回归模型中未发现RDW与残余肾功能之间的相关性。开始PD三个月后，发现第2组和第3组在iPTH方面存在显著差异。多变量回归分析表明，在调整了血红蛋白、白蛋白和白细胞后，RDW升高与PD后相应时期残余肾小球滤过率下降相关（心率=-0.587，95%置信区间-1.080~-0.093）。本研究表明，RDW反映了PD患者PD后相应时期的残余肾功能。
