Anandan Arun Karat, Balachandran Pradeep, Chowksey Arpitha, Sankaranarayanan Gomathy, Samuel Usha
Department of Nephrology, Government T. D. Medical College, Alappuzha, Kerala, India.
Saudi J Kidney Dis Transpl. 2018 Sep-Oct;29(5):1211-1215. doi: 10.4103/1319-2442.243968.
Acute renal cortical necrosis is a rare cause of intrinsic acute kidney injury (AKI) which is commonly associated with obstetric complications such as placental abruption and some serious systemic disorders such as hemolytic-uremic syndrome, sepsis, severe burns, and snake bite. Acute pancreatitis is an extremely rare cause of renal cortical necrosis, and only less than 10 cases are reported in the literature. Here, we present a 24-year-old male presented with features of acute pancreatitis and oliguric AKI. His pancreatic enzymes were above 1000 IU/mL at admission. He was initiated on hemodialysis. Percutaneous renal biopsy done at 4 week of illness showed features of diffuse renal cortical necrosis. Contrast-enhanced computed tomography demonstrated hypoattenuation of cortex compared to medulla consistent with renal cortical necrosis. He developed complications such as acute necrotic collection, pleural effusion and retinal detachment in addition to renal cortical necrosis which was managed conservatively. Since there was no improvement in the renal function now, he is being evaluated for renal transplantation.
急性肾皮质坏死是导致肾性急性肾损伤(AKI)的一种罕见病因,通常与胎盘早剥等产科并发症以及溶血尿毒综合征、脓毒症、严重烧伤和蛇咬伤等一些严重的全身性疾病相关。急性胰腺炎是肾皮质坏死极其罕见的病因,文献报道的病例不足10例。在此,我们报告一名24岁男性,表现为急性胰腺炎和少尿性AKI。入院时其胰酶高于1000 IU/mL。他开始接受血液透析。病程第4周进行的经皮肾活检显示弥漫性肾皮质坏死的特征。对比增强计算机断层扫描显示皮质相对于髓质呈低密度,符合肾皮质坏死。除肾皮质坏死外,他还出现了急性坏死性积液、胸腔积液和视网膜脱离等并发症,这些并发症均采取保守治疗。由于目前肾功能没有改善,他正在接受肾移植评估。