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[哌柏西利作为新型检查点抑制剂的治疗经验]

[Treatment Experience of Palbociclib as a New Checkpoint Inhibitor].

作者信息

Sakurai Kenichi, Fujisaki Shigeru, Kubota Hitomi, Suzuki Yuna, Hara Yukiko, Suzuki Shuhei, Adachi Keita, Tomita Ryouichi, Enomoto Katsuhisa, Hirano Tomohiro, Saga Reina, Makishima Makoto

机构信息

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

出版信息

Gan To Kagaku Ryoho. 2018 Oct;45(10):1498-1500.

Abstract

We encountered a case of multiple metastases from breast cancer. The patient was administered palbociclib, which was a new checkpoint inhibitor. The patient received various chemotherapies and endocrine therapies. We observed episode of care, a harm phenomenon, and tolerability. We did not recognize adverse events more severe than Grade 3 during the 6 weeks after initiating palbociclib therapy. Diagnostic imaging showed that the metastatic lesions maintained stable disease during the 6 weeks after initiating palbociclib therapy. This case suggested that palbociclib therapy is useful for patients with metastatic breast cancer.

摘要

我们遇到了一例乳腺癌多发转移的病例。该患者接受了帕博西尼治疗,这是一种新型检查点抑制剂。患者接受了多种化疗和内分泌治疗。我们观察了护理过程、不良现象和耐受性。在开始帕博西尼治疗后的6周内,我们未发现比3级更严重的不良事件。诊断性影像学检查显示,在开始帕博西尼治疗后的6周内,转移病灶病情保持稳定。该病例表明,帕博西尼治疗对转移性乳腺癌患者有用。

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