Metabolic Bone Disease Unit, Columbia University College of P&S, PH8W-864, 630 West 168th Street, New York, NY 10032, USA.
Endocrinol Metab Clin North Am. 2018 Dec;47(4):825-837. doi: 10.1016/j.ecl.2018.07.008.
Chronic parathyroid hormone (PTH) deficiency has a marked effect on the skeleton, leading to characteristic decreases in bone remodeling and increases in bone mass. Numerous lines of evidence using biochemical, imaging, and histomorphometric methodologies have demonstrated that the skeleton is altered when PTH is absent and that these abnormalities might be reversed with PTH treatment. More evidence is needed to determine whether fracture risk is altered in hypoparathyroidism.
慢性甲状旁腺激素（PTH）缺乏对骨骼有显著影响，导致骨重建减少和骨量增加。使用生化、成像和组织形态计量学方法的大量证据表明，当 PTH 缺乏时，骨骼会发生改变，并且这些异常可能随着 PTH 治疗而逆转。需要更多的证据来确定甲状旁腺功能减退症是否会改变骨折风险。
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