The University of Queensland, Brisbane QLD, Australia.
Queensland University of Technology, Brisbane QLD, Australia.
Neurosci Biobehav Rev. 2018 Dec;95:438-448. doi: 10.1016/j.neubiorev.2018.10.020. Epub 2018 Nov 1.
Childhood obesity is an issue of public health concern that is understood to emerge due to disequilibrium in energy homeostasis. This commentary explores literature regarding neuro-biological mechanisms of energy homeostasis and the relationship between subjective measures of children's eating behaviours and objective measures of appetite, in order to better understand the aetiology of childhood obesity. Early life influences, such as in utero exposure, breastfeeding, and general disadvantage, appear to have an important influence on neuro-biological mechanisms of appetite and may contribute to inequitable distributions of obesity within the population. Subject measures of eating behaviours appear to capture various aspects of neuro-biologically driven (objective) appetite systems, however, these systems are complex, interdependent and not yet fully understood. Future research focusing attention on early life influences on appetite and eating behaviours is warranted to increase understanding of differences in rates of obesity within the population, to determine opportunities for targeted obesity prevention initiatives, and to explore the potential to measure change in eating behaviours as a marker of appetite and obesity risk.
儿童肥胖是一个公共卫生关注的问题,据了解,它是由于能量平衡失调而出现的。本评论探讨了有关能量平衡的神经生物学机制以及儿童饮食行为的主观测量与食欲的客观测量之间关系的文献,以便更好地了解儿童肥胖的病因。早期生活的影响,如宫内暴露、母乳喂养和一般劣势,似乎对食欲的神经生物学机制有重要影响,并可能导致肥胖在人群中的分布不均。饮食行为的主观测量似乎可以捕捉到神经生物学驱动的(客观)食欲系统的各个方面,然而,这些系统是复杂的、相互依存的,尚未完全理解。未来的研究需要关注早期生活对食欲和饮食行为的影响,以增加对人群中肥胖率差异的理解,确定有针对性的肥胖预防措施的机会,并探讨将饮食行为的改变作为食欲和肥胖风险的标志物进行测量的潜力。