Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD.
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD; Institute of Gerontology, University of Georgia College of Public Health, Athens, GA.
Arch Phys Med Rehabil. 2019 May;100(5):874-882. doi: 10.1016/j.apmr.2018.10.008. Epub 2018 Nov 2.
To examine trends in 12-month postfracture residual disability, nursing home placement, and mortality among patients with a hip fracture between 1990 and 2011.
Secondary analysis of 12-month outcomes from 3 cohort studies and control arms of 2 randomized controlled trials.
Original studies were conducted as part of the Baltimore Hip Studies (BHS).
Community-dwelling patients ≥65 years of age hospitalized for surgical repair of a nonpathologic hip fracture (N=988).
Twelve-month residual disability, mortality, and nursing home residency were examined in case-mix adjusted models by sex and study. Residual disability was calculated by subtracting prefracture scores of Lower Extremity Physical Activities of Daily Living from scores at 12 months postfracture. We also examined the proportion of individuals with a 12-month score higher than their prefracture score (residual disability>0).
Only small improvements were seen in residual disability between 1990 and 2011. No significant differences were seen for men between BHS2 (enrollment 1990-1991; mean residual disability=3.1 activities; 95% confidence interval [CI], 2.16-4.10) and BHS7 (enrollment 2006-2011; mean=3.1 activities; 95% CI, 2.41-3.82). In women, residual disability significantly improved from BHS2 (mean=3.5 activities; 95% CI, 2.95-3.99) to BHS3 (enrollment 1992-1995; mean=2.7 activities; 95% CI, 2.01-3.30) with no significant improvements in later studies. After adjustment, a substantial proportion (91% of men and 79% of women) had a negative outcome (residual disability, died, or nursing home residence at 12 months) in the most recently completed study (BHS7).
Over 2 decades, patients undergoing usual care post-hip fracture still had substantial residual disability. Additional clinical and research efforts are needed to determine how to improve hip fracture treatment, rehabilitation, and subsequent outcomes.
研究 1990 年至 2011 年间髋部骨折患者 12 个月后残留残疾、入住养老院和死亡率的趋势。
对 3 项队列研究和 2 项随机对照试验的对照臂的 12 个月结果进行二次分析。
原始研究作为巴尔的摩髋部研究(BHS)的一部分进行。
社区居住的年龄≥65 岁的患者,因非病理性髋部骨折接受手术修复住院(N=988)。
通过性别和研究在病例混合调整模型中检查 12 个月时的残留残疾、死亡率和养老院居住情况。通过从骨折前的下肢日常生活活动能力评分中减去 12 个月后的评分来计算残留残疾。我们还检查了 12 个月时评分高于骨折前评分(残留残疾>0)的个体比例。
仅在 1990 年至 2011 年间观察到残留残疾的微小改善。BHS2(1990-1991 年入组;平均残留残疾=3.1 项活动;95%置信区间[CI],2.16-4.10)和 BHS7(2006-2011 年入组;平均=3.1 项活动;95%CI,2.41-3.82)之间的男性没有显著差异。在女性中,残留残疾从 BHS2(平均=3.5 项活动;95%CI,2.95-3.99)显著改善到 BHS3(1992-1995 年入组;平均=2.7 项活动;95%CI,2.01-3.30),而在随后的研究中没有显著改善。调整后,最近完成的研究(BHS7)中相当大比例(91%的男性和 79%的女性)存在不良结局(12 个月时残留残疾、死亡或养老院居住)。
在过去 20 年中,接受常规护理的髋部骨折患者仍存在严重的残留残疾。需要进一步的临床和研究努力,以确定如何改善髋部骨折的治疗、康复和随后的结果。