Kitsantas Panagiota, Nirmalraj Lavanya
From George Mason University, College of Health and Human Services, Department of Health Administration and Policy, Fairfax, Virginia.
South Med J. 2018 Nov;111(11):698-702. doi: 10.14423/SMJ.0000000000000881.
The purpose of this study was to examine the association between respiratory syncytial virus (RSV) infection in early infancy and health conditions such as asthma and respiratory allergies at 6 years of age in a cohort of US children born at term with no medical issues at birth.
Data (1542 records) from the Infant Feeding Practices Study II and the Year Six Follow-Up study were used in the analysis. Descriptive statistics and logistic regression were conducted to estimate the magnitude and direction of potential associations between children's health conditions such as asthma, hay fever, or respiratory allergy, and RSV infection during infancy.
A substantial proportion of children with RSV infection in infancy were reported to have developed asthma (10.3%) and hay fever or respiratory allergy (9.4%) by 6 years of age. Analyses revealed that children with RSV infection in infancy were more likely to develop asthma (odds ratio 1.99, 95% confidence interval 1.06-3.74), and hay fever or respiratory allergy (odds ratio 2.13, 95% confidence interval 1.28-3.57) by 6 years of age. In addition, the risk of developing asthma and hay fever or respiratory allergy by 6 years of age increased considerably with a family history of these conditions.
Our findings support the need for understanding and monitoring the long-term health outcomes of RSV infection in infancy. Appropriate prevention and treatment measures for RSV infection during infancy may reduce the incidence of associated long-term adverse health outcomes. Knowledge of the long-term complications of RSV infection in infancy, such as asthma, hay fever, or respiratory allergy, can aid in the prevention and better management of these health conditions.
本研究旨在调查美国足月出生且出生时无健康问题的儿童队列中，婴儿早期呼吸道合胞病毒（RSV）感染与6岁时哮喘和呼吸道过敏等健康状况之间的关联。
分析使用了来自婴儿喂养实践研究II和六年随访研究的数据（1542条记录）。进行描述性统计和逻辑回归，以估计儿童健康状况（如哮喘、花粉症或呼吸道过敏）与婴儿期RSV感染之间潜在关联的程度和方向。
据报告，婴儿期感染RSV的儿童中有很大一部分在6岁时患哮喘（10.3%）以及花粉症或呼吸道过敏（9.4%）。分析显示，婴儿期感染RSV的儿童在6岁时更有可能患哮喘（优势比1.99，95%置信区间1.06 - 3.74）以及花粉症或呼吸道过敏（优势比2.13，95%置信区间1.28 - 3.57）。此外，若有这些疾病的家族史，6岁时患哮喘和花粉症或呼吸道过敏的风险会大幅增加。
我们的研究结果支持有必要了解和监测婴儿期RSV感染的长期健康后果。婴儿期针对RSV感染采取适当的预防和治疗措施可能会降低相关长期不良健康后果的发生率。了解婴儿期RSV感染的长期并发症，如哮喘、花粉症或呼吸道过敏，有助于预防和更好地管理这些健康状况。
