Gomer R H, Firtel R A
Science. 1987 Aug 14;237(4816):758-62. doi: 10.1126/science.3039657.
The developmental fate of individual cells has been examined in a system that allows Dictyostelium discoideum cells to differentiate in the absence of aggregation. The results show that the propensity of single amoebae to differentiate into either prespore or prestalk cells occurs by a cell-autonomous mechanism dependent on the cell's position in the cell cycle at the initiation of development. Cells that divide between approximately 1 1/2 hours before and approximately 40 minutes after the differentiation-inducing starvation become prestalk, whereas cells dividing at other times become prespore cells. These results suggest mechanisms by which an initial proportioning of the two cell types within the aggregate is achieved.
在一个能使盘基网柄菌细胞在不发生聚集的情况下进行分化的系统中，对单个细胞的发育命运进行了研究。结果表明，单个变形虫分化为前孢子细胞或前柄细胞的倾向，是通过一种细胞自主机制发生的，该机制取决于发育开始时细胞在细胞周期中的位置。在诱导分化的饥饿前约1个半小时至饥饿后约40分钟之间进行分裂的细胞会成为前柄细胞，而在其他时间进行分裂的细胞则会成为前孢子细胞。这些结果提示了在聚集体中实现两种细胞类型初始比例分配的机制。
