癌症患者使用骨重塑药物引发的非典型股骨骨折（AFF）
Atypical Femoral Fractures (AFF) from Bone Remodeling Agents in Patients with Cancer.
作者信息
Kordoni Maria, Rigakos Georgios, Kim Young Hun Minjoo, Kaklamanis Loukas, Nikolatou-Galitis Ourania, Hadjiyassemi Lina, Labropoulos Stefanos, Razis Evangelia
机构信息
3rd Department of Oncology, Hygeia Hospital, Athens, Greece.
3rd Department of Oncology, Hygeia Hospital, Athens, Greece
出版信息
Anticancer Res. 2018 Nov;38(11):6439-6444. doi: 10.21873/anticanres.13005.
Anti-resorptive drugs like bisphosphonates (BP) and denosumab are widely used for prevention and treatment of skeletal diseases, such as osteoporosis and bone metastases and mainly work through the prevention of osteoclast-mediated bones resorption. BP can lead to atypical femoral fractures (AFF) that is a rare, easily misdiagnosed treatment-related complication with great impact on the quality of life of patients. We present a concise review of the literature on BP related AFF based on the cases of 3 breast cancer patients that reflect the diagnostic pitfall of this rare entity. In conclusion, breast cancer patients very often are exposed to BP use and are at risk of developing AFF.
抗骨吸收药物如双膦酸盐（BP）和地诺单抗被广泛用于预防和治疗骨骼疾病，如骨质疏松症和骨转移，其主要作用机制是预防破骨细胞介导的骨吸收。BP可导致非典型股骨骨折（AFF），这是一种罕见的、易被误诊的与治疗相关的并发症，对患者生活质量有很大影响。我们基于3例乳腺癌患者的病例对与BP相关的AFF的文献进行简要综述，这些病例反映了这种罕见病症的诊断陷阱。总之，乳腺癌患者经常使用BP，有发生AFF的风险。
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