Pavlovic Mladen, Gajovic Nevena, Jurisevic Milena, Mitrovic Slobodanka, Radosavljevic Gordana, Pantic Jelena, Arsenijevic Nebojsa, Jovanovic Ivan
Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Serbia.
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia.
Gastroenterol Res Pract. 2018 Oct 4;2018:6578273. doi: 10.1155/2018/6578273. eCollection 2018.
Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects.
The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed. Expression of IL-32, VEGF, IL-17, and CD31 was measured by immunohistochemistry.
IL-32 expression was significantly lower in tissue samples from patients with diffuse type of gastric cancer that is also a severe and more progressive form (TNM stages III and IV, poor histological differentiation, and higher nuclear grade III). Expression of IL-17 was also decreased in patients with diffuse type of gastric cancer. Microvascular density was diminished in diffuse type of gastric cancer.
Downregulated expression of IL-32 in tumor tissue of patients with diffuse type of gastric cancer may implicate on its role in limiting ongoing proinflammatory and proangiogenic processes. This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer.
胃癌（GC）是全球最常见的癌症之一，通常在晚期被诊断出，预后较差，这表明需要新的诊断和预后标志物。本研究的目的是确定白细胞介素-32（IL-32）、促炎和血管生成介质在弥漫性和肠型胃癌患者中的表达及其与临床病理特征的关系。
分析了70例胃癌患者弥漫性和肠型肿瘤的组织样本。采用免疫组织化学法检测IL-32、血管内皮生长因子（VEGF）、白细胞介素-17（IL-17）和CD31的表达。
弥漫性胃癌患者的组织样本中IL-32表达显著降低，弥漫性胃癌也是一种严重且进展性更强的类型（TNM分期为III期和IV期、组织学分化差、核分级为III级更高）。弥漫性胃癌患者的IL-17表达也降低。弥漫性胃癌的微血管密度降低。
弥漫性胃癌患者肿瘤组织中IL-32表达下调可能暗示其在限制持续的促炎和促血管生成过程中的作用。这强调了IL-32在弥漫性胃癌生物学中未被认识的作用。
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