镍催化的 N,O-双齿导向基团促进的芳基碘代芳烃与芳酰胺的区域选择性芳基化反应。
Nickel-catalyzed regioselective arylation of aromatic amides with aryl iodides enabled by an N,O-bidentate directing group.
机构信息
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
出版信息
Org Biomol Chem. 2018 Nov 21;16(45):8783-8790. doi: 10.1039/c8ob02237b.
PMID:30403224
Abstract
A bidentate directing group enabled regioselective arylation of C(sp2)-H bonds in aromatic carboxamides with aryl iodides under nickel-catalysis is reported, which provides the corresponding products in moderate to good yields. This protocol using the inexpensive and low-toxic Ni catalyst can tolerate a wide range of functional groups.
摘要
一种双齿导向基团使得在镍催化下芳基酰胺中 C(sp2)-H 键的区域选择性芳基化反应成为可能，该反应以中等至良好的收率得到相应的产物。该方法使用廉价且低毒的 Ni 催化剂，可以容忍广泛的官能团。
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