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一项系统回顾和荟萃分析揭示了儿童睾丸扭转后的真实结局。

A systematic review and meta-analysis revealing realistic outcomes following paediatric torsion of testes.

机构信息

Royal Hospital for Children, 1345 Govan Road, Glasgow, G51 4TF, United Kingdom.

Royal Hospital for Children, 1345 Govan Road, Glasgow, G51 4TF, United Kingdom.

出版信息

J Pediatr Urol. 2018 Dec;14(6):503-509. doi: 10.1016/j.jpurol.2018.09.017. Epub 2018 Oct 5.

Abstract

INTRODUCTION

Reported testicular loss rates following paediatric testicular torsion often reflect the surgical decision-making process, rather than long-term survival of the testes.

OBJECTIVES

We aim to perform systematic analysis and meta-analysis to investigate testicular salvage rates and to assess predictors of long-term viability.

STUDY DESIGN

Systematic review according to PRISMA guidelines was performed to investigate immediate and long-term (>12 months) testicular loss rates following torsion in the paediatric population. Literature search and study inclusion were performed by two investigators. A study quality score was derived and attributed to each study. Predictors of testicular loss were described. Proportions meta-analysis was performed with random effects modelling, and testing for heterogeneity.

RESULTS

Twelve studies were includedm, 6 reporting early orchidectomy rates, and 6 reporting long-term outcomes. Study quality was generally low.

DISCUSSION

The mean early testicular loss rate was 39%, whereas meta-analysis revealed late loss to approach 50%. Predictors of outcomes include prehospital symptom duration, location of presentation, transfer to a tertiary centre, social affluence and use of ultrasound prior to diagnosis or transfer.

CONCLUSIONS

This study has shown a considerable late testicular loss rate, which must be relayed to families even after testicular salvage. Delay in time to presentation is consistently found to predict poor outcomes.

摘要

简介

小儿睾丸扭转后报告的睾丸丢失率往往反映了手术决策过程,而不是睾丸的长期存活。

目的

我们旨在进行系统分析和荟萃分析,以调查睾丸保存率,并评估长期存活的预测因素。

研究设计

根据 PRISMA 指南进行系统评价,以调查小儿睾丸扭转后立即和长期(>12 个月)睾丸丢失率。两名研究人员进行了文献检索和研究纳入。对每个研究进行了研究质量评分,并进行了描述。描述了睾丸丢失的预测因素。采用随机效应模型进行了比例荟萃分析,并进行了异质性检验。

结果

共纳入 12 项研究,其中 6 项报告了早期睾丸切除术率,6 项报告了长期结果。研究质量普遍较低。

讨论

早期睾丸丢失率的平均值为 39%,而荟萃分析显示晚期丢失率接近 50%。结局的预测因素包括发病前的症状持续时间、就诊地点、转至三级中心、社会富裕程度以及在诊断或转院前使用超声。

结论

本研究显示了相当高的晚期睾丸丢失率,即使在睾丸保存后,也必须向家属转达。就诊时间的延迟始终被发现与不良结局相关。

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