Sánchez Bruno, Calderón Cristian, Tapia Ricardo A, Contreras Renato, Campodónico Paola R
Departamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
Centro de Química Médica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Front Chem. 2018 Oct 23;6:509. doi: 10.3389/fchem.2018.00509. eCollection 2018.
Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish intramolecular hydrogen bond which may be activated by the reaction media and/or the nature of the nucleophile.
以4-氯喹唑啉与苯胺和肼的亲核芳香取代反应作为模型体系,通过实验表明,在芳香环上带有杂原子作为取代基的底物能够形成分子内氢键,该氢键可能会被反应介质和/或亲核试剂的性质所激活。