调节性 B 细胞：炎症性和自身免疫性风湿病的新角色。
Regulatory B cells: New players in inflammatory and autoimmune rheumatic diseases.
机构信息
Department of Rheumatology and clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa 41 110, Greece.
Division of Rheumatology, Department of Internal Medicine, University of Patras, Rio, Patras, Greece.
出版信息
Semin Arthritis Rheum. 2019 Jun;48(6):1133-1141. doi: 10.1016/j.semarthrit.2018.10.007. Epub 2018 Oct 15.
OBJECTIVE
Regulatory B cells (Bregs) are a new subset of B cells with immunoregulatory functions, mainly through IL-10 production. Bregs suppress inflammatory Th1 and Th17 differentiation and induce Tregs suppressing autoimmune diseases. The aim of the study was to review the literature related to Bregs in autoimmune rheumatic diseases (ARDs).
METHODS
A literature review of publications in PUBMED published in English was performed using the relevant combinations of terms.
RESULTS
All relevant publications are discussed. Overall, recent studies in rheumatic diseases found Bregs to be decreased in ANCA-associated vasculitides (AAV) and in systemic sclerosis (SSc), particularly in SSc-associated lung fibrosis. In AAV Bregs levels are negatively correlated with autoantibody levels whereas in SSc this association is less clear but there is an inverse association with Th1 and Th17 cells. In rheumatoid arthritis (RA), Bregs were decreased, particularly in RA-associated lung fibrosis. In psoriatic arthritis IL-10 + Bregs are decreased and inversely associated with Th1 and Th17 cells. In systemic lupus erythematosus (SLE), the role of Bregs is unclear. In experimental diseases, when Bregs were expanded ex-vivo, they ameliorated established disease.
CONCLUSION
Bregs appear to be a new player in the pathogenesis of ARDs, and may offer a new strategy for therapeutic intervention.
目的
调节性 B 细胞（Bregs）是具有免疫调节功能的 B 细胞的一个新亚群，主要通过产生 IL-10 来发挥作用。Bregs 抑制炎症性 Th1 和 Th17 分化，并诱导 Tregs 抑制自身免疫性疾病。本研究旨在综述与自身免疫性风湿病（ARDs）相关的 Bregs 文献。
方法
通过使用相关术语组合，在 PUBMED 上以英文发表的文献中进行文献回顾。
结果
讨论了所有相关出版物。总体而言，最近在风湿病中的研究发现，在抗中性粒细胞胞质抗体相关性血管炎（AAV）和系统性硬化症（SSc）中，Bregs 减少，尤其是在 SSc 相关的肺纤维化中。在 AAV 中，Bregs 水平与自身抗体水平呈负相关，而在 SSc 中，这种相关性不太清楚，但与 Th1 和 Th17 细胞呈负相关。在类风湿关节炎（RA）中，Bregs 减少，尤其是在 RA 相关的肺纤维化中。在银屑病关节炎中，IL-10+Bregs 减少，并与 Th1 和 Th17 细胞呈负相关。在系统性红斑狼疮（SLE）中，Bregs 的作用尚不清楚。在实验性疾病中，当体外扩增 Bregs 时，它们可改善已建立的疾病。
结论
Bregs 似乎是 ARDs 发病机制中的一个新参与者，可能为治疗干预提供新策略。
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