Toronto Western Hospital and Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Occup Med (Lond). 2018 Dec 26;68(9):587-592. doi: 10.1093/occmed/kqy137.
Cleaning agents have been commonly implicated as causative or triggering factors in work-related asthma (WRA), mainly from epidemiologic studies. Relatively few clinical series have been reported.
We aimed to compare socio-demographic and clinical features among tertiary clinic patients with WRA exposed to cleaning and non-cleaning products.
Analyses were conducted on a patient database containing 208 patients with probable WRA referred to the asthma and airway centre at a tertiary centre hospital in Canada from 2000 to 2014. Chi-squared and independent samples t-tests were used to analyse categorical and continuous data, respectively.
Twenty-two (11%) WRA cases were attributed to a variety of cleaning product exposures, 12 were diagnosed as occupational asthma (OA) and 10 as work-exacerbated asthma (WEA) (10% of all OA and 11% of all WEA). There were multiple exposures and the responsible agent(s) could seldom be clearly identified. Most frequent categories of exposure were surfactants, alcohols, disinfectants and acids. Compared to WRA with other exposures, those with cleaning agent exposures had a significantly larger proportion of females (82 versus 35%, P < 0.001), included a higher percentage of workers in healthcare (41 versus 4%, P < 0.001), and submitted more workers' compensation claims (86 versus 64%, P = 0.05). Other characteristics were comparable.
In a tertiary referral clinic, patients with WRA from cleaning agent exposure had clinical characteristics that were similar to those with WRA from other causes. Most frequent exposures were surfactants, alcohols, disinfectants and acids.
清洁剂已被普遍认为是导致工作相关哮喘（WRA）的原因或触发因素，主要来自流行病学研究。相对较少有临床系列报道。
我们旨在比较暴露于清洁和非清洁产品的三级诊所 WRA 患者的社会人口统计学和临床特征。
对 2000 年至 2014 年期间在加拿大一家三级中心医院的哮喘和气道中心就诊的 208 例可能患有 WRA 的患者的患者数据库进行了分析。使用卡方检验和独立样本 t 检验分别分析分类和连续数据。
22 例（11%）WRA 病例归因于各种清洁产品暴露，12 例被诊断为职业性哮喘（OA），10 例为工作加重哮喘（WEA）（所有 OA 的 10%和所有 WEA 的 11%）。存在多种暴露，并且很难明确确定责任代理人。最常见的暴露类别是表面活性剂、醇类、消毒剂和酸。与暴露于其他试剂的 WRA 相比，暴露于清洁试剂的 WRA 患者中女性比例明显更高（82%对 35%，P < 0.001），包括更多的医疗保健工作者（41%对 4%，P < 0.001），并提交了更多的工人赔偿申请（86%对 64%，P = 0.05）。其他特征相似。
在三级转诊诊所中，暴露于清洁试剂的 WRA 患者的临床特征与其他原因引起的 WRA 患者相似。最常见的暴露是表面活性剂、醇类、消毒剂和酸。
