小纤维神经病变皮肤活检结果中的性别差异：一项回顾性病历审查

Gender Differences in Skin Biopsy Findings in Small Fiber Neuropathy: A Retrospective Chart Review.

作者信息

Weaver Joshua, Kim Kyung-Wha, Carey Bridget T, Langsdorf Jennifer A, Chin Russell L

机构信息

Department of Neurology, Weill Cornell Medical College, New York, NY.

出版信息

J Clin Neuromuscul Dis. 2018 Dec;20(2):69-75. doi: 10.1097/CND.0000000000000228.

DOI:10.1097/CND.0000000000000228

PMID:30439752

Abstract

OBJECTIVES

To determine whether there are gender differences in the clinical presentation or skin biopsy measures of nerve fiber density in patients with small fiber neuropathy (SFN).

METHODS

Retrospective chart review of subjects with suspected SFN.

RESULTS

Of 218 cases (137 women and 81 men) with suspected SFN, 96 (44%), including 63% of the men and 33% of the women (P < 0.05), had low epidermal nerve fiber density (ENFD) or sweat gland nerve fiber density (SGNFD). There were no differences in the clinical presentation between men and women. In those with abnormal findings, low ENFD alone was more frequent in women than men (51.1% vs. 7.8%, P < 0.05), whereas abnormal SGNFD alone was more frequent in men than women (68.6% vs. 11.1%, P < 0.05). Both SGNFD and ENFD were low in 23.5% of men and 33.3% of women. Skin biopsy findings were independent of clinical presentation or etiology.

CONCLUSIONS

The clinical presentation of SFN is similar in men and women. In skin biopsy studies, low ENFD is more common in women and low SGNFD in men.

摘要

目的

确定小纤维神经病变（SFN）患者在临床表现或神经纤维密度的皮肤活检测量方面是否存在性别差异。

方法

对疑似SFN的受试者进行回顾性病历审查。

结果

在218例疑似SFN的病例中（137例女性和81例男性），96例（44%）的表皮神经纤维密度（ENFD）或汗腺神经纤维密度（SGNFD）较低，其中男性占63%，女性占33%（P<0.05）。男女之间的临床表现没有差异。在有异常发现的患者中，单纯ENFD低在女性中比男性更常见（51.1%对7.8%，P<0.05），而单纯SGNFD异常在男性中比女性更常见（68.6%对11.1%，P<0.05）。23.5%的男性和33.3%的女性ENFD和SGNFD均较低。皮肤活检结果与临床表现或病因无关。