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硬膜下积脓:一种罕见且死亡率高的疾病的病例报告

Subdural empyema case report of a rare disease with a high mortality.

作者信息

Dedeciusová M, Tyll T, Beneš V, Netuka D

出版信息

Rozhl Chir. 2018 Spring;97(6):279-285.

PMID:30442008
Abstract

Subdural empyema is a rare purulent intracranial infection. Outcome is dependent on the preoperative level of consciousness, therefore an early diagnosis and urgent neurosurgical intervention are necessary. Mortality of subdural empyema remains high, ranging from 6% to 15%. The case report presents a patient with subdural empyema which resulted from sinusitis. The integral and first part of therapy was an urgent neurosurgical drainage of subdural empyema, followed by functional endoscopic sinus surgery performed by ENT surgeon. Conservative treatment consisted of systemic antibiotics and antiedematous therapy. Later the patient developed post-infectious hydrocephalus, which was solved by implantation of a ventriculo-peritoneal shunt. Consequently, cranioplasty was performed. Despite acute onset of the disease and severe neurologic deficit prior to the first neurosurgical intervention, the clinical condition of the patient is favorable after multiple surgeries. The patient is able to live independently without any significant limitations in everyday activities. The presenting symptoms of subdural empyema are reflective of increased intracranial pressure, meningeal irritation, and cerebritis. Radiographic imaging (contrast CT, DWI-MRI, contrast MRI) is an essential diagnostic tool. The integral part of therapy is a neurosurgical evacuation of subdural empyema combined with intravenous antibiotic therapy. Subdural empyema is a rare, rapidly progressing disease which is underestimated by the physicians in many cases. Diagnosis is often delayed and therefore, despite recent progress in treatment, the mortality rate remains high. Key words: empyema - subdural - sinusitis - diagnostic imaging - surgical method.

摘要

硬脑膜下积脓是一种罕见的颅内化脓性感染。预后取决于术前意识水平,因此早期诊断和紧急神经外科干预是必要的。硬脑膜下积脓的死亡率仍然很高,在6%至15%之间。该病例报告介绍了一名因鼻窦炎导致硬脑膜下积脓的患者。治疗的主要和首要部分是紧急神经外科引流硬脑膜下积脓,随后由耳鼻喉科医生进行功能性鼻内镜鼻窦手术。保守治疗包括全身使用抗生素和抗水肿治疗。后来患者出现感染后脑积水,通过植入脑室-腹腔分流管得以解决。随后进行了颅骨成形术。尽管疾病急性发作且在首次神经外科干预前存在严重神经功能缺损,但经过多次手术后患者的临床状况良好。患者能够独立生活,日常活动没有任何明显限制。硬脑膜下积脓的临床表现反映了颅内压升高、脑膜刺激和脑实质炎症。影像学检查(增强CT、DWI-MRI、增强MRI)是重要的诊断工具。治疗的主要部分是神经外科清除硬脑膜下积脓并联合静脉抗生素治疗。硬脑膜下积脓是一种罕见、进展迅速的疾病,在许多情况下被医生低估。诊断往往延迟,因此尽管近期治疗取得了进展,但死亡率仍然很高。关键词:积脓 - 硬脑膜下 - 鼻窦炎 - 诊断成像 - 手术方法

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