如果您想阻止 III 型 CRISPR 核糖核酸酶，那么您应该给它戴上一个环（核酸酶）。

If You'd Like to Stop a Type III CRISPR Ribonuclease, Then You Should Put a Ring (Nuclease) on It.

机构信息

Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA.

Laboratory of Bacteriology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

出版信息

Mol Cell. 2018 Nov 15;72(4):608-609. doi: 10.1016/j.molcel.2018.10.048.

DOI:10.1016/j.molcel.2018.10.048

PMID:30444997

Abstract

Athukoralage et al. (2018) identify a new class of nuclease that degrades cyclic oligoadenylate (cOA), a second messenger that activates non-specific RNA degradation by the type III CRISPR-Cas accessory RNase Csm6/Csx1. This discovery provides a mechanism for regulating the degradation of foreign transcripts during the type III CRISPR immune response.

摘要

Athukoralage 等人（2018 年）鉴定出一种新型核酸酶，可降解环化寡腺苷酸（cOA），cOA 是一种第二信使，可激活由 III 型 CRISPR-Cas 辅助 RNA 酶 Csm6/Csx1 介导的非特异性 RNA 降解。这一发现为 III 型 CRISPR 免疫反应中外源转录本降解的调控提供了机制。