女性生殖系统癌症中的尿促性腺激素片段（UGF）。I. 敏感性和特异性，与其他标志物的比较。

Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers.

作者信息

Cole L A, Schwartz P E, Wang Y X

机构信息

Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.

出版信息

Gynecol Oncol. 1988 Sep;31(1):82-90. doi: 10.1016/0090-8258(88)90273-9.

DOI:10.1016/0090-8258(88)90273-9

PMID:3044936

Abstract

UGF is a mixture of human chorionic gonadotropin free beta-subunit and its fragments, and is detected in pregnancy and trophoblast disease urines. An examination of 67 nonpregnant cancer-free women showed average urine levels of 0.13 ng/ml. Six of the 67 (8.9%) had levels exceeding a selected cutoff value, 0.2 ng/ml. Of 112 woman with active gynecologic cancer, 72 (64%) had urine UGF levels exceeding this cutoff value. When urines were limited to those with creatinine greater than 0.5 mg/ml, or to first morning samples (mean creatinine 1.0 ng/ml), the sensitivity of UGF for all gynecologic cancers was raised to 76%. The sensitivity of UGF for cervical (73%), for endometrial (65%), and for ovarian (83%) cancers exceeded that of plasma CA 125 and lipid-associated sialic acid in plasma (LASA) in the same population. UGF is an exciting new tumor marker which warrants further evaluation.

摘要

尿促性腺激素片段（UGF）是游离人绒毛膜促性腺激素β亚基及其片段的混合物，可在妊娠尿液和滋养层疾病尿液中检测到。对67名未怀孕且无癌症的女性进行检测，结果显示尿液平均水平为0.13 ng/ml。67名女性中有6名（8.9%）的水平超过选定的临界值0.2 ng/ml。在112名患有活动性妇科癌症的女性中，72名（64%）的尿液UGF水平超过该临界值。当尿液限制为肌酐大于0.5 mg/ml的尿液或首次晨尿样本（平均肌酐1.0 ng/ml）时，UGF对所有妇科癌症的敏感性提高到76%。在同一人群中，UGF对宫颈癌（73%）、子宫内膜癌（65%）和卵巢癌（83%）的敏感性超过血浆CA 125和血浆脂质相关唾液酸（LASA）。UGF是一种令人兴奋的新型肿瘤标志物，值得进一步评估。