Shi L-H, Huang J-Y, Liu Y-Z, Chiou J-Y, Wu R, Wei J C-C
1 Department of Immunology and Rheumatology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
2 Department of Medical Research, Chung Shan Medical University Hospital, Taichung.
Lupus. 2018 Dec;27(14):2279-2283. doi: 10.1177/0961203318809179.
Viral infection contributing to systemic lupus erythematosus (SLE) development has been largely reported. However, the SLE risk in patients with human papillomavirus (HPV) infection is unknown.
Data were retrieved from the Longitudinal Health Insurance Database (2000) in Taiwan. We identified 43,567 patients with HPV infection and 174,268 age- and sex-matched uninfected controls from 2002 to 2012. Individuals were followed up from index date (first date of diagnosis with HPV) until the occurrence of SLE, at the end of the study (December 2013), or when they were withdrawn from the insurance program. The incidence rate ratio (IRR) was calculated using the univariate Poisson regression. The adjusted hazard ratios (aHRs) were calculated, and sensitive and subgroups analyses were also conducted.
Compared with the non-HPV controls, the IRR of SLE in HPV patients was 1.52 (95% confidence interval (CI): 1.09-2.12). The risk of SLE in HPV-infected individuals was significantly high (aHR: 1.48, 95% CI: 1.06-2.06) after adjusting for age, sex, and comorbidities. Men aged between 16 and 45 years were more susceptible to developing SLE (aHR: 21.57, 95% CI: 2.52-184.60, p = 0.0051).
Our study showed a significantly higher risk of SLE among HPV-infected patients, especially in men aged between 16 and 45 years.
大量报道称病毒感染与系统性红斑狼疮（SLE）的发生有关。然而，人乳头瘤病毒（HPV）感染患者患SLE的风险尚不清楚。
数据取自台湾纵向健康保险数据库（2000）。我们从2002年至2012年确定了43567例HPV感染患者以及174268例年龄和性别匹配的未感染对照者。个体从索引日期（首次诊断为HPV的日期）开始随访，直至发生SLE、研究结束时（2013年12月）或退出保险计划。使用单变量泊松回归计算发病率比（IRR）。计算调整后的风险比（aHR），并进行敏感性和亚组分析。
与非HPV对照者相比，HPV患者发生SLE的IRR为1.52（95%置信区间（CI）：1.09 - 2.12）。在调整年龄、性别和合并症后，HPV感染个体患SLE的风险显著更高（aHR：1.48，95%CI：1.06 - 2.06）。年龄在16至45岁之间的男性更易患SLE（aHR：21.57，95%CI：2.52 - 184.60，p = 0.0051）。
我们的研究表明，HPV感染患者患SLE的风险显著更高，尤其是年龄在16至45岁之间的男性。
