Demouveaux Bastien, Gouyer Valérie, Magnien Mylène, Plet Ségolène, Gottrand Frédéric, Narita Tetsuharu, Desseyn Jean-Luc
Inserm, Université de Lille, CHU Lille, LIRIC UMR 995, F-59000 Lille, France.
PSL Research University, UPMC Univ. Paris 06, ESPCI Paris, CNRS UMR 7615, Laboratoire Sciences et Ingénierie de la Matière Molle, 10, rue Vauquelin, 75231, Paris Cedex 05, France - Global Station for Soft Matter, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japon.
Med Sci (Paris). 2018 Oct;34(10):806-812. doi: 10.1051/medsci/2018206. Epub 2018 Nov 19.
Mucus is the first line of innate mucosal defense in all mammals. Gel‑forming mucins control the rheological properties of mucus hydrogels by forming a network in which hydrophilic and hydrophobic regions coexist, and it has been revealed that the network is formed through both covalent links and reversible links such as hydrophobic interactions in order to modulate the structure as a function of the physiological necessities. Here, we review the structure and functions of the mucus in terms of the gel-forming mucins protein-protein interactions, also called interactome. Since it is difficult to characterize the low energy reversible interactions due to their dependence on physico-chemical environment, their role is not well understood. Still, they constitute a promising target to counteract mucus abnormalities observed in mucus-associated diseases.
黏液是所有哺乳动物先天性黏膜防御的第一道防线。形成凝胶的黏蛋白通过形成一个亲水和疏水区域共存的网络来控制黏液水凝胶的流变特性，并且已经发现该网络是通过共价键和诸如疏水相互作用等可逆键形成的，以便根据生理需要调节结构。在此，我们从形成凝胶的黏蛋白蛋白质-蛋白质相互作用（也称为相互作用组）的角度综述黏液的结构和功能。由于低能量可逆相互作用依赖于物理化学环境，难以对其进行表征，因此它们的作用尚未得到充分理解。尽管如此，它们仍是对抗黏液相关疾病中观察到的黏液异常的一个有前景的靶点。
