Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir 190006, India.
Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir 190006, India.
Mutat Res Rev Mutat Res. 2018 Oct-Dec;778:1-12. doi: 10.1016/j.mrrev.2018.07.002. Epub 2018 Aug 8.
Nonalcoholic fatty liver disease (NAFLD) is a major health concern associated with increased mortality due to cardiovascular disease, type II diabetes, insulin resistance, liver disease, and malignancy. The molecular mechanism underlying these processes is not fully understood but involves hepatic fat accumulation and alteration of energy metabolism and inflammatory signals derived from various cell types including immune cells. During the last two decades, epigenetic mechanisms have emerged as important regulators of chromatin alteration and the reprogramming of gene expression. Recently, epigenetic mechanisms have been implicated in the pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH) genesis. Epigenetic mechanisms could be used as potential therapeutic targets and as noninvasive diagnostic biomarkers for NAFLD. These mechanisms can determine disease progression and prognosis in NAFLD. In this review, we discuss the role of epigenetic mechanisms in the progression of NAFLD and potential therapeutic targets for the treatment of NAFLD.
非酒精性脂肪性肝病（NAFLD）是一个主要的健康问题，与心血管疾病、2 型糖尿病、胰岛素抵抗、肝脏疾病和恶性肿瘤导致的死亡率增加有关。这些过程的分子机制尚不完全清楚，但涉及肝脂肪积累以及来自包括免疫细胞在内的各种细胞类型的能量代谢和炎症信号的改变。在过去的二十年中，表观遗传机制已成为染色质改变和基因表达重编程的重要调节因子。最近，表观遗传机制被牵连到 NAFLD 和非酒精性脂肪性肝炎（NASH）的发病机制中。表观遗传机制可作为 NAFLD 的潜在治疗靶点和非侵入性诊断生物标志物。这些机制可以决定 NAFLD 的疾病进展和预后。在这篇综述中，我们讨论了表观遗传机制在 NAFLD 进展中的作用以及治疗 NAFLD 的潜在治疗靶点。
