Şendur Ruba, Özcabı Bahar, Mutlu Gül Yeşiltepe, Bozaykut Abdulkadir
Clinic of Pediatrics, Zeynep Kamil Women's and Children's Diseases Training and Research Hospital, İstanbul, Turkey.
Division of Pediatric Endocrinology, Zeynep Kamil Women's and Children's Diseases Training and Research Hospital, İstanbul, Turkey.
Turk Pediatri Ars. 2018 Sep 1;53(3):169-176. doi: 10.5152/TurkPediatriArs.2018.6210. eCollection 2018 Sep.
Obesity is a more common and important health problem in childhood. We aimed to determine sociodemographic and clinical factors contributing weight loss.
Medical records of 120 obese patients (6-18 years old) applied at least twice for follow-up between 2012 (January)-2016 (September) were reviewed. Age, gender, socioeconomic status, family obesity, comorbidities, medications, operations, exercise frequency, screen time, physical examination findings and biochemical/hormone values [thyroid hormone, fasting insulin/glucose, cholesterol levels, Homeostasis model assesment insulin resistance (HOMA-IR), oral glucose tolerance test results (if applied) were recorded. Patients with a difference between the initial and last body mass index standart deviation higher than -0.2 were defined as "the good losing weight" group; the rest as "the poorly losing weight" group. The SPSS 22.0 program was used for analyzes.
Puberty stage showed a significant difference (p=0,019); 65% of patients in the poorly losing weight group but 54% of other group were at stage 4-5. The initial body mass index standart deviation and exercise frequency were higher in the good losing weight group, the last measured body mass index standart deviation was lower (p=0). In the other group, baseline HOMA-IR was higher (p=0.037); there were more metformin-initiated patients but the difference was not significant.
We observed that exercise frequency was higher in cases with good weight loss; therefore, we consider that increasing physical activity is an important step. Other crucial outcomes are that the initial body mass index standart deviation is higher while HOMA-IR is lower in those cases and that puberty stage is higher in poorly weight losing patients.
肥胖在儿童期是一个更为常见且重要的健康问题。我们旨在确定导致体重减轻的社会人口统计学和临床因素。
回顾了2012年1月至2016年9月期间至少两次前来随访的120例肥胖患者（6 - 18岁）的病历。记录年龄、性别、社会经济状况、家族肥胖情况、合并症、用药情况、手术情况、运动频率、屏幕使用时间、体格检查结果以及生化/激素值[甲状腺激素、空腹胰岛素/血糖、胆固醇水平、稳态模型评估胰岛素抵抗（HOMA - IR）、口服葡萄糖耐量试验结果（若进行了该项检查）]。初始和末次体重指数标准差差值高于 - 0.2的患者被定义为“体重减轻良好”组；其余患者为“体重减轻不佳”组。使用SPSS 22.0程序进行分析。
青春期阶段存在显著差异（p = 0.019）；体重减轻不佳组中65%的患者处于4 - 5期，而另一组为54%。体重减轻良好组的初始体重指数标准差和运动频率更高，末次测量的体重指数标准差更低（p = 0）。在另一组中，基线HOMA - IR更高（p = 0.037）；开始使用二甲双胍的患者更多，但差异不显著。
我们观察到体重减轻良好的患者运动频率更高；因此，我们认为增加身体活动是重要的一步。其他关键结果是，这些患者的初始体重指数标准差更高而HOMA - IR更低，且体重减轻不佳的患者青春期阶段更高。
