Department of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research, Affiliated to Uttarakhand Technical University, Kashipur, India.
Pharmacognosy and Phytotherapy Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata -700032, India.
Curr Top Med Chem. 2018;18(20):1792-1803. doi: 10.2174/1568026619666181120125525.
Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It significantly causes fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems, characterized by microcephaly along with Guillain-Barré syndrome, issuing ZIKV a major public health concern as declared by the World Health Organization. There is hardly any FDA approved anti-Zika viral drugs available.
Therefore, it is a big panic for the scientists to destroy the virus completely by generating potent inhibitors.
For the purpose, various Zika viral targets were explored by structure-based design in the present review in connection with the discovery of various synthetic and natural sourced inhibitors against Zika virus.
The structure-based drug design tools such as x-ray crystallography and molecular docking reported various co-crystallized ligands and Zika virus inhibitors.
Such inhibitors could further be modified for the design of highly active leads to combat Zika virus utilizing chemoinformatics modules.
寨卡病毒是一种通过埃及伊蚊传播的全球性严重病毒。它会引起发热、关节疼痛或皮疹、结膜炎等症状。感染寨卡病毒的孕妇可能会因严重的神经问题而导致胎儿畸形，其特征是小头畸形和格林-巴利综合征，世界卫生组织宣布寨卡病毒是一个主要的公共卫生关注点。目前几乎没有获得 FDA 批准的抗寨卡病毒药物。
因此，科学家们通过生成有效的抑制剂来彻底消灭病毒，这引起了极大的恐慌。
为此，本综述通过基于结构的设计方法探讨了各种寨卡病毒靶标，并结合了针对寨卡病毒的各种合成和天然来源抑制剂的发现。
基于结构的药物设计工具，如 X 射线晶体学和分子对接，报告了各种共结晶配体和寨卡病毒抑制剂。
这些抑制剂可以进一步修饰，利用化学信息学模块设计出高度活跃的针对寨卡病毒的先导化合物。
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