BACKGROUND

Posttransplantation diabetes mellitus (PTDM) is a frequent metabolic complication following solid organ transplantation and was proven to be associated with adverse outcome. This study aimed to identify the incidence and risk factors of PTDM under the background of relative-living renal transplantation in China.

METHODS

We conducted a retrospective cohort study that included 358 recipients who underwent relative-living donor kidney transplantation in the Organ Transplant Institute of 309th Hospital of People's Liberation Army between January 1, 2010, and December 31, 2014. PTDM was defined based on American Diabetes Association criteria. Demographics and laboratory results were compared between patients with PTDM and non-PTDM; multivariate analysis was performed using a logistic regression model.

RESULTS

One hundred ten out of a total of 358 recipients were diagnosed with PTDM (30.72%) within 3 years after transplantations. Seven risk factors for PTDM were identified in multivariate analysis: body mass index ≥25 (odds ratio [OR] 1.905, 95% confidence interval [CI]: 1.114-3.258), family history of diabetes (OR 1.898, CI: 1.051-3.258), hypomagnesemia pretransplantation (OR 1.871, CI: 1.133-3.092), acute rejection episodes in 3 months posttransplantation (OR 2.312, CI: 1.015-5.268), tacrolimus use (OR 1.952, CI: 1.169-3.258), impaired fasting glucose diagnosed pretransplantation (OR 1.807, CI: 1.091-2.993), and hyperglycemia in the first week posttransplantation (OR 1.856, CI: 1.133-3.043).

CONCLUSION

Our study suggests high body mass index, family diabetes history, hypomagnesemia pretransplantation, acute rejection episodes within the first 3 months after transplantation, tacrolimus use, impaired fasting glucose diagnosed pretransplantation, and hyperglycemia within the first week after transplantation are independent risk factors of PTDM in relative-living donor transplantation.