Tangamornsuksan Wimonchat, Lohitnavy Ornrat, Sruamsiri Rosarin, Chaiyakunapruk Nathorn, Norman Scholfield C, Reisfeld Brad, Lohitnavy Manupat
Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University , Phitsanulok , Thailand.
Arch Environ Occup Health. 2019;74(5):225-238. doi: 10.1080/19338244.2018.1492894. Epub 2018 Nov 25.
To reconcile and unify available results regarding paraquat exposure and Parkinson's disease (PD), we conducted a systematic review and meta-analysis to provide a quantitative estimate of the risk of PD associated with paraquat exposure. Six scientific databases including PubMed, Cochrane libraries, EMBASE, Scopus, ISI Web of Knowledge, and TOXLINE were systematically searched. The overall odds ratios (ORs) with corresponding 95% CIs were calculated using a random-effects model. Of 7,309 articles identified, 13 case control studies with 3,231 patients and 4,901 controls were included into our analysis. Whereas, one prospective cohort studies was included into our systematic review. A subsequent meta-analysis showed an association between PD and paraquat exposure (odds ratio = 1.64 (95% CI: 1.27-2.13; = 24.8%). There is a statistically significant association between paraquat exposure and PD. Thus, future studies regarding paraquat and Parkinson's disease are warranted.
为了协调和统一关于百草枯暴露与帕金森病（PD）的现有研究结果，我们进行了一项系统评价和荟萃分析，以定量评估百草枯暴露与PD相关的风险。我们系统检索了包括PubMed、Cochrane图书馆、EMBASE、Scopus、ISI Web of Knowledge和TOXLINE在内的六个科学数据库。使用随机效应模型计算总体比值比（OR）及相应的95%置信区间（CI）。在检索到的7309篇文章中，我们纳入了13项病例对照研究（3231例患者和4901例对照）进行分析。此外，我们的系统评价还纳入了一项前瞻性队列研究。随后的荟萃分析显示，PD与百草枯暴露之间存在关联（比值比 = 1.64（95% CI：1.27 - 2.13；P = 24.8%）。百草枯暴露与PD之间存在统计学显著关联。因此，有必要开展关于百草枯与帕金森病的进一步研究。
