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小儿上尿路重复畸形的部分肾切除术:不同手术入路与技术的比较

Pediatric Partial Nephrectomy for Upper Urinary Tract Duplication Anomalies: A Comparison Between Different Surgical Approaches and Techniques.

作者信息

Neheman Amos, Kord Eyal, Strine Andrew C, VanderBrink Brian A, Minevich Eugene A, DeFoor William R, Reddy Pramod P, Noh Paul H

机构信息

Department of Urology, Assaf Harofeh Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel.

Department of Urology, Assaf Harofeh Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel.

出版信息

Urology. 2019 Mar;125:196-201. doi: 10.1016/j.urology.2018.11.026. Epub 2018 Nov 24.

Abstract

OBJECTIVE

To review and compare 4 different surgical approaches for partial nephrectomy of a nonfunctioning moiety in children with upper urinary tract duplication anomalies.

MATERIALS AND METHODS

A retrospective review of all pediatric patients who underwent open partial nephrectomy (OPN), laparoscopic partial nephrectomy (LPN), robotic partial nephrectomy (RPN), or laparoendoscopic single site partial nephrectomy (LESS-PN) for the treatment of a nonfunctioning moiety in a duplicated collecting system at 2 medical centers between 2007 and 2017. Patient demographics, perioperative data, surgical techniques, complications, and results were compared.

RESULTS

A total of 59 pediatric patients underwent partial nephrectomy for an upper urinary tract duplication anomaly during a 10-year period: 24 OPN, 7 LPN, 18 RPN, and 10 LESS-PN. Median age was 16 months (interquartile range 9-49.7). Median weight was 10.7 Kg (interquartile range 8.8-16.4). Median estimated blood loss was comparable between all minimally invasive approaches, but significantly increased in the open approach. OPN required more narcotics (0.554 mg Morphine equivalent/Kg/day, range 0.03-6.13) and Acetaminophen (72.12 mg/Kg/day, range 0-209.06) than all other groups in the study. Median operating time in OPN (154.5 minutes, range 108-413) and LESS-PN (140 minutes, range 65-245) were found to be significantly shorter in comparison to LPN (190 minutes, range 159-355), and RPN (256 minutes, range 163-458); (P = .03, .005, .02, and .005).

CONCLUSION

Minimally invasive approaches (LPN, RPN, and LESS-PN) for partial nephrectomy in upper urinary tract duplication anomalies may be associated with decreased postoperative analgesia requirements, shorter hospital stay, less blood loss, and less use of drains in comparison to the open approach, while demonstrating efficacy and safety.

摘要

目的

回顾并比较4种不同手术方法用于治疗上尿路重复畸形患儿无功能部分的肾部分切除术。

材料与方法

对2007年至2017年期间在2个医学中心接受开放性肾部分切除术(OPN)、腹腔镜肾部分切除术(LPN)、机器人辅助肾部分切除术(RPN)或单孔腹腔镜肾部分切除术(LESS-PN)治疗重复集合系统中无功能部分的所有儿科患者进行回顾性研究。比较患者的人口统计学资料、围手术期数据、手术技术、并发症及结果。

结果

在10年期间,共有59例儿科患者因上尿路重复畸形接受了肾部分切除术:24例OPN、7例LPN、18例RPN和10例LESS-PN。中位年龄为16个月(四分位间距9 - 49.7)。中位体重为10.7千克(四分位间距8.8 - 16.4)。所有微创方法的中位估计失血量相当,但开放手术的失血量显著增加。与研究中的所有其他组相比,OPN需要更多的麻醉剂(0.554毫克吗啡当量/千克/天,范围0.03 - 6.13)和对乙酰氨基酚(72.12毫克/千克/天,范围0 - 209.06)。发现OPN(154.5分钟,范围108 - 413)和LESS-PN(140分钟,范围65 - 245)的中位手术时间与LPN(190分钟,范围159 - 355)和RPN(256分钟,范围163 - 458)相比显著更短;(P = 0.03、0.005、0.02和0.005)。

结论

与开放手术相比,上尿路重复畸形肾部分切除术的微创方法(LPN、RPN和LESS-PN)可能与术后镇痛需求减少、住院时间缩短、失血量减少及引流管使用减少相关,同时显示出有效性和安全性。

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