急性肝衰竭的辅助性部分原位肝移植
Auxiliary partial orthotopic liver transplantation for acute liver failure.
作者信息
Shrivastav M, Rammohan A, Reddy M S, Rela M
机构信息
Institute of Liver Disease & Transplantation, Gleneagles Global Health City , Chennai , India.
Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharat Institute of Higher Education & Research , Chennai , India.
出版信息
Ann R Coll Surg Engl. 2019 Mar;101(3):e71-e72. doi: 10.1308/rcsann.2018.0204. Epub 2018 Nov 28.
INTRODUCTION
Auxiliary partial orthotopic liver transplantation (APOLT) in acute liver failure acts as a bridge to native liver regeneration with potential for immunosuppression free survival. While technical concerns limit its universal acceptance, the indications in acute liver failure also need to be examined for this procedure to ultimately succeed.
CASE HISTORY
We present the case of an eight-month-old girl with cryptogenic acute liver failure who underwent APOLT. She developed postoperative liver dysfunction, most likely owing to the persistence of the diseased native liver, ultimately leading to an orthotopic retransplantation. She remains well on follow-up review.
CONCLUSIONS
A tempered approach to selecting patients for APOLT (especially with regard to aetiology of acute liver failure) makes it a safe and effective alternative to orthotopic liver transplantation.
引言
急性肝衰竭患者行辅助性部分原位肝移植（APOLT）可作为天然肝脏再生的桥梁，具有无免疫抑制存活的潜力。尽管技术问题限制了其广泛应用，但为使该手术最终成功，还需对急性肝衰竭的适应证进行研究。
病例报告
我们报告一例8个月大的不明原因急性肝衰竭女童接受APOLT的病例。她术后出现肝功能障碍，很可能是由于病变的天然肝脏持续存在，最终导致再次原位肝移植。随访复查时她情况良好。
结论
对选择APOLT患者采取审慎的方法（尤其是在急性肝衰竭病因方面），使其成为原位肝移植安全有效的替代方法。
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