Koh Yong Hui, Tan Li Yi, Ng Shi-Yan
Institute of Molecular and Cell Biology, Singapore, Singapore.
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Front Cell Neurosci. 2018 Nov 9;12:413. doi: 10.3389/fncel.2018.00413. eCollection 2018.
Parkinson's disease (PD) is an age-associated, progressive neurodegenerative disorder characterized by motor impairment and in some cases cognitive decline. Central to the disease pathogenesis of PD is a small, presynaptic neuronal protein known as alpha synuclein (a-syn), which tends to accumulate and aggregate in PD brains as Lewy bodies or Lewy neurites. Numerous and studies confirm that a-syn aggregates can be propagated from diseased to healthy cells, and it has been suggested that preventing the spread of pathogenic a-syn species can slow PD progression. In this review, we summarize the works of recent literature elucidating mechanisms of a-syn propagation, and discussed the advantages in using patient-derived induced pluripotent stem cells (iPSCs) and/or induced neurons to study a-syn transmission.
帕金森病（PD）是一种与年龄相关的进行性神经退行性疾病，其特征为运动障碍，在某些情况下还伴有认知衰退。PD发病机制的核心是一种称为α-突触核蛋白（α-syn）的小的突触前神经元蛋白，它在PD患者大脑中倾向于聚积并形成路易小体或路易神经突。大量研究证实，α-syn聚集体可从病变细胞传播至健康细胞，并且有人提出，阻止致病性α-syn物种的传播可减缓PD的进展。在本综述中，我们总结了近期文献中阐明α-syn传播机制的研究工作，并讨论了使用患者来源的诱导多能干细胞（iPSC）和/或诱导神经元来研究α-syn传播的优势。
