美国未断奶奶牛犊牛中具有人畜共患性和遗传多样性的 Blastocystis 亚型。
Zoonotic and genetically diverse subtypes of Blastocystis in US pre-weaned dairy heifer calves.
机构信息
U.S. Department of Agriculture, Beltsville, MD, USA.
U.S. Department of Agriculture, Fort Collins, CO, USA.
出版信息
Parasitol Res. 2019 Feb;118(2):575-582. doi: 10.1007/s00436-018-6149-3. Epub 2018 Nov 27.
Blastocystis is an emerging zoonotic pathogen with global distribution. However, limited data exist on the prevalence and genetic diversity of Blastocystis in the USA and in food animals. We conducted the first large-scale molecular investigation of Blastocystis in the USA by testing 2539 fecal samples from dairy heifer calves from 13 states. Blastocystis was detected in 73 (2.9%) fecal samples and in 10 of the 13 tested states. Molecular characterization showed a wide diversity of subtypes. Eleven subtypes were identified, seven previously reported (ST-3, ST-4, ST-5, ST-10, ST-14, ST-17, and ST-21) and four potentially novel subtypes (named ST-23 to ST-26). Zoonotic subtypes 3, 4, and 5 were found in 67% (49) of the positive specimens in this population. Our results suggest that cattle could serve as reservoirs of infection for humans and other domestic animals highlighting the potential risk of zoonotic transmission for Blastocystis.
芽囊原虫是一种具有全球分布的新兴人畜共患病原体。然而，关于美国和食品动物中芽囊原虫的流行率和遗传多样性的数据有限。我们通过测试来自 13 个州的 2539 份奶牛小母牛粪便样本，对美国的芽囊原虫进行了首次大规模的分子调查。在 73 份（2.9%）粪便样本中检测到芽囊原虫，在 13 个检测州中的 10 个州中检测到。分子特征显示出广泛的亚型多样性。鉴定出 11 种亚型，其中 7 种为已报道的（ST-3、ST-4、ST-5、ST-10、ST-14、ST-17 和 ST-21），4 种可能为新型亚型（命名为 ST-23 至 ST-26）。在该人群中，67%（49 个）阳性标本中发现了 3、4 和 5 型人畜共患病原体。我们的研究结果表明，牛可能是人类和其他家畜感染的宿主，突出了芽囊原虫人畜共患病传播的潜在风险。
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