Arcispedale Santa Maria Nuova, Reggio Emilia, Italy -
Azienda ULSS 22 Bussolengo, Regione Veneto, Verona, Italy.
Panminerva Med. 2019 Sep;61(3):422-428. doi: 10.23736/S0031-0808.18.03582-6. Epub 2018 Nov 27.
Bronchial thermoplasty (BT) is an innovative non-pharmacological endoscopic treatment for patients with severe persistent asthma based on controlled heat release with a device called Alair™ Catheter (Boston Scientific, Natick, MA, USA). The Alair™ system is the first device that works by delivering radiofrequency or thermal energy to selectively reduce the amount of airway smooth muscle (ASM) in bronchi. Literature showed significant improvement in clinical outcomes such as symptom control, severe exacerbation rate, hospitalization, quality of life, and number of working or school days lost for asthma. Besides smooth muscle effects changes in inflammatory pattern after BT have been documented. Bronchial thermoplasty requires an experienced physician who had a proficiency training in bronchoscopy and had rigor, dexterity and a thorough knowledge of the airway anatomy. Furthermore, right selection of severe asthma patient is crucial in order to have best response after BT. This article reviews BT device description and how to perform the procedure. Criteria for right selection and management of patient before and after BT will be discussed.
支气管热成形术(BT)是一种创新性的非药物性内镜治疗方法,适用于严重持续性哮喘患者,其原理是利用一种名为 Alair™导管(波士顿科学公司,马萨诸塞州纳提克)的设备来控制热量释放。Alair™系统是首个通过传递射频或热能来选择性减少支气管气道平滑肌(ASM)数量的设备。文献表明,该设备在临床结果方面有显著改善,如症状控制、严重恶化率、住院率、生活质量以及因哮喘而丧失的工作或上学天数。除平滑肌效应外,BT 后炎症模式的变化也有记录。支气管热成形术需要有经验的医生来操作,这些医生需要经过支气管镜检查方面的专业培训,具备严谨性、灵活性以及对气道解剖结构的全面了解。此外,正确选择严重哮喘患者对于 BT 后的最佳疗效至关重要。本文综述了 BT 设备的描述以及操作方法。还将讨论 BT 前和 BT 后患者的选择标准和管理。