Siomi H, Shida H, Nam S H, Nosaka T, Maki M, Hatanaka M
Institute for Virus Research Kyoto University, Japan.
Cell. 1988 Oct 21;55(2):197-209. doi: 10.1016/0092-8674(88)90043-8.
The posttranscriptional regulator (p27x-III) of human T cell leukemia virus type I (HTLV-I) is located predominantly in the cell nucleolus. A highly basic amino-terminal sequence (NH2-Met-Pro-Lys-Thr-Arg-Arg-Arg-Pro-Arg-Arg-Ser-Gln-Arg-Lys-Arg-Pro-Pro -Thr- Pro) in this protein, when fused to the amino termini of beta-galactosidase and p40x of HTLV-I, acts as an autonomous signal capable of directing the hybrid proteins to the cell nucleolus.
人类嗜T淋巴细胞病毒I型（HTLV-I）的转录后调节因子（p27x-III）主要位于细胞核仁中。该蛋白中一个高度碱性的氨基末端序列（NH2-甲硫氨酸-脯氨酸-赖氨酸-苏氨酸-精氨酸-精氨酸-精氨酸-脯氨酸-精氨酸-精氨酸-丝氨酸-谷氨酰胺-精氨酸-赖氨酸-精氨酸-脯氨酸-脯氨酸-苏氨酸-脯氨酸），当与β-半乳糖苷酶的氨基末端以及HTLV-I的p40x融合时，可作为一种自主信号，能够将杂合蛋白导向细胞核仁。
