Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Instituto Nacional de Neurología y Neurocirugía, SSA, Mexico City, Mexico.
Ann N Y Acad Sci. 2019 Feb;1437(1):43-56. doi: 10.1111/nyas.13985. Epub 2018 Nov 29.
Sepsis occurs when a systemic infection induces an uncontrolled inflammatory response that results in generalized organ dysfunction. The exacerbated peripheral inflammation can induce, in turn, neuroinflammation which may result in severe impairment of the central nervous system (CNS). Indeed, the ensuing blood-brain barrier disruption associated with sepsis promotes glial activation and starts a storm of proinflammatory cytokines in the CNS that leads to brain dysfunction in sepsis survivors. Endotoxic shock induced in mice by peripheral injection of lipopolysaccharides closely resembles the peripheral and central inflammation observed in sepsis. In this review, we provide an overview of the neuroinflammatory features in sepsis and of recent progress toward the development of new anti-neuroinflammatory therapies seeking to reduce mortality and morbidity in sepsis survivors.
当全身感染引起失控的炎症反应导致全身性器官功能障碍时，就会发生败血症。外周炎症的加剧会反过来引起神经炎症，从而导致中枢神经系统（CNS）严重受损。事实上，败血症相关的血脑屏障破坏会促进神经胶质细胞的激活，并在中枢神经系统引发一场促炎细胞因子的风暴，导致败血症幸存者的大脑功能障碍。通过外周注射脂多糖诱导的小鼠内毒素休克，与败血症中观察到的外周和中枢炎症非常相似。在这篇综述中，我们概述了败血症中的神经炎症特征，以及为开发新的抗神经炎症疗法以降低败血症幸存者的死亡率和发病率所取得的最新进展。
