曲安奈德在小切口玻璃体切割术治疗眼内膜剥除术中的应用。

Triamcinolone in small-gauge vitrectomy for epiretinal membrane peeling.

机构信息

Department of Ophthalmology, Medical University Innsbruck, Innsbruck, Austria..

Department of Ophthalmology, Medical University Innsbruck, Innsbruck, Austria.

出版信息

Can J Ophthalmol. 2018 Dec;53(6):632-636. doi: 10.1016/j.jcjo.2018.01.023. Epub 2018 Apr 2.

DOI:10.1016/j.jcjo.2018.01.023

PMID:30502990

Abstract

OBJECTIVE

We compared visual and macular morphological outcomes after epiretinal membrane (ERM) peeling, with and without IVTA treatment.

DESIGN

Interventional, retrospective, consecutive case-control study.

PARTICIPANTS

Forty-one eyes of 41 participants (17 men, 24 women) were included. Twenty-one were treated by standard vitrectomy and peeling (controls) and 20 patients received intravitreal triamcinolone after vitrectomy and peeling.

METHODS

Pre-and postoperative letter score and central foveal thickness (CFT) through the foveal centre were compared between both groups. Best-corrected visual acuity (BCVA) was measured using Snellen charts and converted to logMAR for statistical analyses.

RESULTS

CFT and BCVA had improved by the 6-month follow-up from baseline. In the control group, the mean logMAR BCVA improved from 0.57 (SD: 0.22) to 0.21 (0.17) (p < 0.01), and the mean CFT reduced from 462.5 (98.6) µm to 329.8 (82.7) µm (p < 0.01). The mean logMAR BCVA of the IVTA group improved from 0.73 (0.17) to 0.36 (0.31) (p < 0.01), and the mean CFT reduced from 561.45 (131.0) µm to 339.25 (72.6) µm (p < 0.01). Visual improvement and CFT did not differ significantly at follow up (p = 0.583; p= 0.85). Significant reduction of CFT is seen in the IVTA group (p = 0.048).

CONCLUSIONS

Visual acuity and macular morphology improved after ERM peeling, with or without IVTA. Although conjunctive IVTA did not significantly influence visual outcome at 6 months, a significant decrease in CFT was observed after IVTA administration.

摘要

目的

我们比较了外膜剥除术（ERM）联合和不联合玻璃体内曲安奈德（IVTA）治疗后，患者的视力和黄斑形态的变化。

设计

介入性、回顾性、连续病例对照研究。

参与者

纳入 41 名患者（17 名男性，24 名女性）的 41 只眼。21 只眼接受标准玻璃体切除术和外膜剥除术（对照组），20 只眼接受玻璃体切除术后玻璃体内曲安奈德注射治疗。

方法

比较两组患者治疗前后的中心视力和黄斑中心凹厚度（CFT）。最佳矫正视力（BCVA）使用 Snellen 图表进行测量，并转换为 logMAR 进行统计学分析。

结果

与基线相比，两组患者在 6 个月的随访中 CFT 和 BCVA 均有改善。对照组的平均 logMAR BCVA 从 0.57（标准差：0.22）提高到 0.21（0.17）（p<0.01），平均 CFT 从 462.5（98.6）μm 降低到 329.8（82.7）μm（p<0.01）。IVTA 组的平均 logMAR BCVA 从 0.73（0.17）提高到 0.36（0.31）（p<0.01），平均 CFT 从 561.45（131.0）μm 降低到 339.25（72.6）μm（p<0.01）。在随访时，两组患者的视力改善和 CFT 均无显著差异（p=0.583；p=0.85）。IVTA 组的 CFT 显著降低（p=0.048）。