Wijekoon H M Suranji, Munasinghe D M S, Wijayawardhane K A N, Ariyarathna H M H S, Horadagoda Neil, Rajapakse Jayanthe, De Silva D D Niranjala
Department of Veterinary Pathobiology, Division of Parasitology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka.
Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka.
Vet World. 2018 Nov;11(10):1376-1379. doi: 10.14202/vetworld.2018.1376-1379. Epub 2018 Oct 3.
The objective of this study was to describe and characterize the postmortem and histopathological findings of putative esophageal chondrosarcoma associated with .
Spirocerca-associated esophageal nodules were collected from 54 dogs at postmortem examination and were stained with hematoxylin and eosin. Of the cases examined, 15 were selected randomly for further investigation, of which 11 were classified as non-neoplastic nodules while 4 had changes reflecting a neoplastic process.
In all four neoplastic cases, the wall of the esophageal nodules contained islands and nests of highly proliferative atypical chondroblasts within a cartilaginous matrix. However, there was no statistically significant association between gender (p=0.228), age (p=0.568), and breeds (p>0.05) with the occurrence of spirocercosis. Moreover, all esophageal nodules identified were located near the caudal segment, and their diameters ranged from 1 to 6 cm (4.7±1.5 cm). A number of worms in each nodule varied from 5 to 25 (11.3±5).
Histopathology and cytology revealed that the wall of the esophageal nodules contained islands and nests of highly proliferative atypical chondroblasts within a cartilaginous matrix, a rare finding, and clinical challenge in spirocercosis.
本研究的目的是描述和表征与相关的疑似食管软骨肉瘤的尸检和组织病理学发现。
在尸检时从54只犬收集与螺旋体相关的食管结节，并用苏木精和伊红染色。在所检查的病例中，随机选择15例进行进一步研究，其中11例被分类为非肿瘤性结节，4例有反映肿瘤形成过程的变化。
在所有4例肿瘤病例中，食管结节壁在软骨基质内含有高度增殖的非典型软骨母细胞岛和巢。然而，性别（p = 0.228）、年龄（p = 0.568）和品种（p>0.05）与螺旋体病的发生之间没有统计学上的显著关联。此外，所有确定的食管结节都位于尾段附近，其直径范围为1至6厘米（4.7±1.5厘米）。每个结节中的蠕虫数量从5到25不等（11.3±5）。
组织病理学和细胞学显示，食管结节壁在软骨基质内含有高度增殖的非典型软骨母细胞岛和巢，这是一种罕见的发现，也是螺旋体病的临床挑战。
