Burchardt Ewa, Roszak Andrzej
Department of Radiotherapy and Oncological Gynecology, Greater Poland Cancer Centre, Poznan, Poland.
Department of Electroradiology, Poznan University of Medical Sciences, Poznan, Poland.
Rep Pract Oncol Radiother. 2018 Nov-Dec;23(6):595-603. doi: 10.1016/j.rpor.2018.05.006. Epub 2018 Jun 15.
This article reviews the salient features of recent results of clinical studies. It puts a special emphasis on technical aspects, mechanisms of action together with radiotherapy and chemotherapy and points out areas for additional investigation.
To present the current state of knowledge on hyperthermia (HT) and to highlight its role in the treatment of cervical cancer.
The literature on the clinical use of combined hyperthermia for cervical cancer was analyzed. Clinical outcomes together with the technical aspects and the role of HT were also evaluated.
Clinically randomized trials have demonstrated benefit including survival with the addition of hyperthermia to radiation or chemotherapy in the treatment of cervical cancer without significant acute or late morbidities. The technological advances have led to an effective and safer treatment delivery, thermal treatment planning, thermal dose monitoring and online adaptive temperature modulation.
Due to rapid development over the last decade of hyperthermia systems and new studies at the basic science and clinical level, the perception of hyperthermia as a part of multimodality treatment in cervical cancer has been changed. However, there is still a need for multicentre randomized clinical trials.
本文回顾了近期临床研究结果的显著特征。特别强调了技术方面、与放疗和化疗相关的作用机制，并指出了需要进一步研究的领域。
介绍关于热疗（HT）的当前知识状态，并突出其在宫颈癌治疗中的作用。
分析了关于联合热疗用于宫颈癌临床应用的文献。还评估了临床结果以及热疗的技术方面和作用。
临床随机试验已证明，在宫颈癌治疗中，热疗联合放疗或化疗具有益处，包括提高生存率，且无明显的急性或晚期并发症。技术进步带来了有效且更安全的治疗实施、热疗治疗计划、热剂量监测和在线自适应温度调节。
由于过去十年热疗系统的快速发展以及基础科学和临床层面的新研究，热疗作为宫颈癌多模态治疗一部分的观念已发生改变。然而，仍需要多中心随机临床试验。
