Faculty of Medicine, Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland.
Biostatistics, Department of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Head Neck. 2019 May;41(5):1499-1507. doi: 10.1002/hed.25569. Epub 2018 Dec 11.
The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous-like lesions with high risk of malignancy, and its biomarkers.
A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta-analysis was possible for human papillomavirus (HPV), aneuploidy, Ki-67, and p53.
Aneuploidy was found consistently (I = 0%, P = 0.61) in 92% (95% CI 80%-99%) of the PVL cases. P53 positivity prevalence was 27% (95% CI 15%-40%) in two available studies (I = 0%, P = 0.64). With HPV and Ki-67, the most outlying studies needed to be removed and after that the pooled HPV positivity prevalence (I = 24%, P = 0.27) was 5% (95% CI 0%-14%) and for Ki-67 (I = 9%, P = 0.33) 14% (95% CI 6%-26%).
With the evidence of the current literature, aneuploidy could value as a biomarker of PVL but should be further validated.
本研究旨在更新有关口腔增殖性疣状白斑（PVL）的信息，该病是一种具有高度恶性潜能的疣状病变，且存在相关生物标志物。
对 PVL 及其生物标志物的文献进行系统检索，共显示 19 篇文献中研究的 22 个生物标志物。对人乳头瘤病毒（HPV）、非整倍体、Ki-67 和 p53 进行了 meta 分析。
92%（95%CI80%-99%）的 PVL 病例中一致发现非整倍体（I = 0%，P = 0.61）。两项可用研究中 p53 阳性率为 27%（95%CI15%-40%）（I = 0%，P = 0.64）。对于 HPV 和 Ki-67，需要去除最偏离的研究，然后 HPV 阳性率的合并（I = 24%，P = 0.27）为 5%（95%CI0%-14%），Ki-67 为 14%（95%CI6%-26%）。
根据当前文献证据，非整倍体可能作为 PVL 的生物标志物，但仍需进一步验证。
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