胰腺胰岛中代谢与分泌事件的偶联：己糖转运是否影响阳离子通量？
The coupling of metabolic to secretory events in pancreatic islets: does hexose transport affect cationic fluxes?
作者信息
Malaisse W J, Mahy M, Sener A
机构信息
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
出版信息
J Physiol (Paris). 1988;83(1):32-5.
Poorly metabolized hexoses, such as 3-O-methyl-D-glucose, 2-deoxy-D-glucose and D-galactose failed to reproduce the inhibition of 86Rb outflow, the early inhibition and secondary rise in 45Ca efflux and the stimulation of insulin release evoked by D-glucose in perifused rat islets. Insulin release induced by either D-glucose or 2-ketoisocaproate was also unaffected by 3-O-methyl-D-glucose. It is concluded that hexose transport in islet cells does not represent in itself a significant determinant of the cationic and secretory response to D-glucose.
代谢不佳的己糖，如3-O-甲基-D-葡萄糖、2-脱氧-D-葡萄糖和D-半乳糖，无法重现D-葡萄糖对灌流大鼠胰岛中86Rb流出的抑制、45Ca外流的早期抑制和继发性升高以及胰岛素释放的刺激作用。3-O-甲基-D-葡萄糖对由D-葡萄糖或2-酮异己酸诱导的胰岛素释放也没有影响。得出的结论是，胰岛细胞中的己糖转运本身并不是对D-葡萄糖阳离子和分泌反应的重要决定因素。
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