Kong Fanjiu, Li Yingbo, Liu Xiaoxin
Department of Blood Transfusion, Zibo First Hospital, Zibo, Shandong 255200, P.R. China.
Department of Blood Transfusion, Weihai Central Hospital, Weihai, Shandong 264400, P.R. China.
Exp Ther Med. 2018 Dec;16(6):4712-4716. doi: 10.3892/etm.2018.6804. Epub 2018 Sep 27.
Influence and clinical value of coagulation test on adverse reactions of blood transfusion in patients with major bleeding of ectopic pregnancy were analyzed. Six hundred and twenty-seven cases of ectopic pregnancy admitted to Zibo First Hospital from July 2014 to March 2017 were retrospectively analyzed. The 369 patients who had adverse reactions after blood transfusion were selected as the experimental group. Another 258 patients without adverse reaction after blood transfusion were selected as the control group. Blood samples were collected 8 h before and after blood transfusion in both groups, and blood test was performed including blood count (RBC), white blood cell count (WBC), platelet count (PLT), HB, hematocrit (HCT), as well as indicators of coagulation, including thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB). There was no significant difference between the two groups in blood routine and blood coagulation test (P>0.05). After transfusion, the RBC, WBC, PLT, HB and HCT in the experimental group were significantly lower than those in the control group (P<0.05). TT, PT and APTT were higher than those in the control group (P<0.05), while FIB was significantly lower than that in the control group (P<0.001). The coagulation in the experimental group after blood transfusion was significantly worse than that in the control group. Coagulation test can be used as a marker of adverse reactions after transfusion in patients with massive bleeding in pregnancy, providing reference and guidance for clinical diagnosis and treatment.
分析凝血试验对异位妊娠大出血患者输血不良反应的影响及临床价值。回顾性分析2014年7月至2017年3月淄博市第一医院收治的627例异位妊娠患者。将369例输血后出现不良反应的患者作为试验组，另选258例输血后未出现不良反应的患者作为对照组。两组患者均在输血前后8小时采集血样，进行血常规检查，包括红细胞计数（RBC）、白细胞计数（WBC）、血小板计数（PLT）、血红蛋白（HB）、血细胞比容（HCT），以及凝血指标，包括凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和纤维蛋白原（FIB）。两组患者血常规及凝血试验结果差异无统计学意义（P>0.05）。输血后，试验组RBC、WBC、PLT、HB及HCT均显著低于对照组（P<0.05）。TT、PT及APTT高于对照组（P<0.05），而FIB显著低于对照组（P<0.001）。试验组输血后凝血功能明显差于对照组。凝血试验可作为妊娠大出血患者输血后不良反应的指标，为临床诊断和治疗提供参考和指导。
