Matsuura Rei, Jankins Tanner C, Hill David E, Yang Kin S, Gallego Gary M, Yang Shouliang, He Mingying, Wang Fen, Marsters Rohan P, McAlpine Indrawan, Engle Keary M
Department of Chemistry , The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla , California 92037 , USA . Email:
Pfizer Oncology Medicinal Chemistry , 10770 Science Center Drive , San Diego , California 92121 , USA.
Chem Sci. 2018 Sep 6;9(44):8363-8368. doi: 10.1039/c8sc03081b. eCollection 2018 Nov 28.
A catalytic γ-selective -hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(ii) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting.
利用钯(II)催化剂,通过底物导向方法,开发了一种使用芳基硼酸对烯基羰基化合物进行催化γ-选择性氢芳基化反应的方法。该方法可耐受多种官能化(杂)芳基硼酸以及烯烃上的各种取代模式。初步机理研究表明,转金属化是限速步骤。