Bouteleux Victor, Kodjikian Laurent, Mendes Maud, Agard Emilie, Machkour-Bentaleb Zaïnab, El-Chehab Hussam, Denis Philippe, Mathis Thibaud, Dot Corinne
Hôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France.
Hôpital de la Croix-Rousse - HCL, 103 Grande rue de la Croix Rousse, 69004, Lyon, France.
Graefes Arch Clin Exp Ophthalmol. 2019 Apr;257(4):699-707. doi: 10.1007/s00417-018-04216-8. Epub 2018 Dec 16.
The main objective of this study was to assess choroidal thickness (CT) changes during an exudative recurrence of age-related macular degeneration (AMD).
A real-life prospective non-interventional 9-month study was conducted in two centers in consecutive patients with exudative AMD between November 2016 and July 2017. CT was measured manually in both eyes based on enhanced-depth imaging spectral-domain optical coherence tomography at different follow-up visits scheduled in the morning.
A total of 134 patients were included. Ninety-five patients presented at least one episode, defined by a follow-up visit under controlled condition (dry retina) followed by a visit for exudative recurrence. A total of 119 episodes were analyzed. The mean CT change in the treated eye was + 8.45 ± 13.52 μm (p < 0.001) and + 5.62 ± 14.77 μm (p = 0.009) respectively in the subfoveal area and nasal area. No significant change in CT was observed in the fellow eye. No significant association between CT changes and treatment, number of intravitreal injections, and blood pressure was observed.
CT increased in case of exudative recurrence of neovascular AMD. The increase was mild but significant. Thus, CT could be used as a monitoring criterion, like the central retinal thickness, in AMD management.
本研究的主要目的是评估年龄相关性黄斑变性（AMD）渗出性复发期间脉络膜厚度（CT）的变化。
2016年11月至2017年7月，在两个中心对连续性渗出性AMD患者进行了一项为期9个月的真实世界前瞻性非干预性研究。在早晨安排的不同随访中，基于增强深度成像光谱域光学相干断层扫描手动测量双眼的CT。
共纳入134例患者。95例患者出现至少一次发作，定义为在受控条件下（干性视网膜）随访后出现渗出性复发的随访。共分析了119次发作。治疗眼在黄斑中心凹下区域和鼻侧区域的平均CT变化分别为+8.45±13.52μm（p<0.001）和+5.62±14.77μm（p=0.009）。对侧眼未观察到CT的显著变化。未观察到CT变化与治疗、玻璃体内注射次数和血压之间存在显著关联。
新生血管性AMD渗出性复发时CT增加。这种增加虽轻微但显著。因此，CT可作为AMD管理中类似于中心视网膜厚度的监测标准。
