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默克尔细胞癌:病例系列

Merkel Cell Carcinoma: A Case Series.

作者信息

Zafar S A, Ahmed O M, Boland M R, Aucharaz N, Lal A

出版信息

Ir Med J. 2018 Oct 11;111(9):826.

Abstract

Introduction Merkel cell carcinoma (MCC) is a rare cutaneous tumour that is clinically aggressive with a high local, regional, and distant metastatic potential. Cases Three male patients presented to University Hospital Limerick (UHL) in 2015 with cutaneous lesions of the thorax, buttock and forearm. Once MCC was confirmed, management included surgical wide local excision (WLE) with regional lymph node dissection followed by adjuvant radiotherapy. One patient is in remission. The second has residual locoregional lymph node disease and is undergoing annual CT surveillance. The third had distant metastatic disease and is deceased from an unrelated condition. Discussion This case series highlights the presentation and management of MCC. We also discus relevant guidelines. The management of MCC is complex and there is a need to establish local or national databases to identify and monitor patients with MCC.

摘要

引言

默克尔细胞癌(MCC)是一种罕见的皮肤肿瘤,临床上具有侵袭性,具有较高的局部、区域和远处转移潜能。

病例

2015年,三名男性患者因胸部、臀部和前臂的皮肤病变就诊于利默里克大学医院(UHL)。确诊为MCC后,治疗包括手术广泛局部切除(WLE)及区域淋巴结清扫,随后进行辅助放疗。一名患者已缓解。第二名患者有局部区域淋巴结残留疾病,正在接受年度CT监测。第三名患者有远处转移疾病,因 unrelated condition 去世。

讨论

本病例系列突出了MCC的表现和治疗。我们还讨论了相关指南。MCC的治疗很复杂,需要建立本地或国家数据库来识别和监测MCC患者。

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