循环游离 DNA 在卵巢癌患者中的潜在临床应用。
Potential clinical applications of circulating cell-free DNA in ovarian cancer patients.
机构信息
Cancer Genetics Group,IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto),Porto,Portugal.
Department of Genetics,Portuguese Oncology Institute of Porto (IPO-Porto),Porto,Portugal.
出版信息
Expert Rev Mol Med. 2018 Dec 18;20:e6. doi: 10.1017/erm.2018.5.
Circulating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called 'liquid biopsy', as a non-invasive cancer biomarker has recently received a lot of attention. The present review will focus on studies concerning the potential clinical applications of cfDNA in ovarian cancer patients.
循环游离 DNA（cfDNA）由在血液中自由循环的小 DNA 片段组成。在癌症患者中，cfDNA 的一部分来源于肿瘤细胞，因此含有相同的遗传和表观遗传改变，被称为循环游离肿瘤 DNA。cfDNA（所谓的“液体活检”）作为一种非侵入性癌症生物标志物的潜在用途最近受到了广泛关注。本综述将重点关注 cfDNA 在卵巢癌患者中的潜在临床应用的研究。
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