一种用于幼年大鼠的改良巴恩斯迷宫。
A Modified Barnes Maze for Juvenile Rats.
作者信息
Valibeigi Nazanin, McHail Daniel G, Kimball Carmen L, Dumas Theodore C
机构信息
Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA.
Psychology Department, George Mason University, Fairfax, VA, USA.
出版信息
Bio Protoc. 2018 Nov 20;8(22). doi: 10.21769/BioProtoc.3084.
To better understand neural codes for spatial navigation and to address cognitive development questions, the neurobiology of postnatal hippocampal development is receiving increased attention. While the Morris Water Maze is the gold standard for assessing hippocampal integrity, potential confounds can be difficult to control for in juvenile rodents (around three weeks of age, when spatial navigation ability first emerges) and this wet maze is not amenable to electrophysiological recording. A dry maze alternative with minimal training, like the Barnes Maze adapted for juvenile rats, can help overcome these obstacles. This paper describes in detail the experimental procedure and data analyses for the adapted Barnes maze for juvenile animals.
为了更好地理解空间导航的神经编码并解决认知发展问题，出生后海马体发育的神经生物学受到了越来越多的关注。虽然莫里斯水迷宫是评估海马体完整性的金标准，但在幼年啮齿动物（大约三周龄，此时空间导航能力首次出现）中，潜在的混杂因素可能难以控制，而且这种水迷宫不适合进行电生理记录。一种训练最少的干迷宫替代品，如适用于幼年大鼠的巴恩斯迷宫，有助于克服这些障碍。本文详细描述了适用于幼年动物的巴恩斯迷宫的实验程序和数据分析。
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